ArticleClinical rheumatology2007
Functional disability and health-related quality of life in South Africans with rheumatoid arthritis and systemic lupus erythematosus.
Article in Clinical rheumatology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 80 citations in OpenAlex.
- Predictors of self-reported health-related quality of life in systemic lupus erythematosus.Rheumatology (Oxford, England) · 2013Trial
- Chronic pain is associated with disability: results from a large, population-based survey in South Africa.Pain reports · 2026Article
- Health-related quality of life in Chinese SLE patients: evidence from 1568 SLE patients and 2610 healthy controls.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Psychiatric manifestations of systemic lupus erythematosus: A brief review with two case-reports.SAGE open medical case reports · 2024Article
- Patterns and prevalence of psychiatric morbidity among individuals with rheumatoid arthritis.Reumatologia · 2024Article
- Health-related quality of life in patients with low back pain in a low resource setting: a cross-sectional study at a tertiary hospital in Uganda.African health sciences · 2023Article
- Severe flares are associated with a poorer health-related quality of life (HRQoL) in patients with SLE: data from the Almenara Lupus Cohort.Lupus science & medicine · 2022Article
- Prevalence of depressive symptoms in patients with rheumatoid arthritis at a regional hospital in KwaZulu-Natal, South Africa.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2022Article
- Ability to Participate in Social Activities of Rheumatoid Arthritis Patients Compared with Other Rheumatic Diseases: A Cross-Sectional Observational Study.Diagnostics (Basel, Switzerland) · 2021Article
- Living with systemic lupus erythematosus in South Africa: a bitter pill to swallow.Health and quality of life outcomes · 2019Article
- Living with systemic lupus erythematosus in the developing world.Rheumatology international · 2018Review
- Differential impact of systemic lupus erythematosus and rheumatoid arthritis on health-related quality of life.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017Article
- Health-related quality of life and utility: comparison of ankylosing spondylitis, rheumatoid arthritis, and systemic lupus erythematosus patients in Taiwan.Clinical rheumatology · 2017Article
- Quality of life and acquired organ damage are intimately related to activity limitations in patients with systemic lupus erythematosus.BMC musculoskeletal disorders · 2015Article
- Patient-reported outcome measures for systemic lupus erythematosus clinical trials: a review of content validity, face validity and psychometric performance.Health and quality of life outcomes · 2014Review
- Mental health status of women with rheumatoid arthritis in iran.Iranian Red Crescent medical journal · 2014Article
- Patterns and predictors of joint damage as assessed by the rheumatoid arthritis articular damage (RAAD) score in South Africans with established rheumatoid arthritis.Clinical rheumatology · 2013Article
- An investigation of factors associated with the health and well-being of HIV-infected or HIV-affected older people in rural South Africa.BMC public health · 2012Article
- Health of adults caring for orphaned children in an HIV-endemic community in South Africa.AIDS care · 2011Article
- Quality of life and satisfaction with life in SLE patients-the importance of clinical manifestations.Clinical rheumatology · 2010Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThere is a paucity of data on the impact of chronic rheumatic diseases on functional disability and overall health-related quality of life (HRQOL) in Africans. MATERIALS AND
methodsWe compared Black South Africans (BSA) with rheumatoid arthritis (RA) (n=50) and systemic lupus erythematosus (SLE) (n=50) to geographically and ethnically matched controls cared for at a tertiary care facility. The modified health assessment questionnaire (mHAQ) and Medical Outcome Study short-form 36 (SF-36) scores and indices of disease activity and organ damage were collected from each group.
resultsCompared to the controls, both the RA and SLE groups fared significantly worse in respect of all the domains and summary scales of the SF-36. Compared to the SLE group, the RA group scored significantly worse with respect to the mHAQ disability index (mHAQ-DI), physical function and bodily pain (BP) SF-36 subscales, and SF-36 summary physical component score (SF-PCS). In the RA group, both the mHAQ-DI and SF-PCS correlated strongly (p<0.005) with the tender joint count, patient global assessment, 28-joint composite disease activity score, physician global assessment, and pain score. The SF-PCS showed only a weak inverse correlation with the swollen joint count (r=-0.29, p<0.05). In the SLE group, the systemic lupus erythematosus disease activity index correlated inversely best with the SF-36 general health subscale (r=-0.56, p<0.0001) and, to a lesser extent, with the mental health, BP, and vitality subscales, and SF-PCS and SF-mental component summary scores.
conclusionBoth RA and SLE have profound effects on HRQOL in BSA, with BP and physical disability particularly worse in RA patients. Disease activity, rather than organ damage or sociodemographic characteristics, correlates best with certain aspects of functional disability and HRQOL in both RA and SLE. Further longitudinal studies are needed to assess the clinical utility of measures of functional disability and HRQOL in this population.
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