ArticleMolecular and cellular biology2006
Alternative ESC and ESC-like subunits of a polycomb group histone methyltransferase complex are differentially deployed during Drosophila development.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Polycomb Group Proteins inBiology · 2026Review
- Viruses in LaboratoryViruses · 2023Article
- Co-Immunoprecipitation (Co-Ip) in Mammalian Cells.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Evolutionary adaptation of the Polycomb repressive complex 2.Epigenetics & chromatin · 2022Review
- Article
- Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins.Clinical epigenetics · 2018Review
- Polycomb and Trithorax Group Genes inGenetics · 2017Review
- Evidence of neofunctionalization after the duplication of the highly conserved Polycomb group gene Caf1-55 in the obscura group of Drosophila.Scientific reports · 2017Article
- Review
- Adaptive selection and coevolution at the proteins of the Polycomb repressive complexes in Drosophila.Heredity · 2016Article
- Transcriptional silencing by polycomb-group proteins.Cold Spring Harbor perspectives in biology · 2014Review
- Are we there yet? Initial targeting of the Male-Specific Lethal and Polycomb group chromatin complexes in Drosophila.Open biology · 2014Review
- Elements of the polycomb repressor SU(Z)12 needed for histone H3-K27 methylation, the interface with E(Z), and in vivo function.Molecular and cellular biology · 2013Article
- Polycomb silencing of the Drosophila 4E-BP gene regulates imaginal disc cell growth.Developmental biology · 2013Article
- The enhancer of trithorax and polycomb gene Caf1/p55 is essential for cell survival and patterning in Drosophila development.Development (Cambridge, England) · 2011Article
- Spps, a Drosophila Sp1/KLF family member, binds to PREs and is required for PRE activity late in development.Development (Cambridge, England) · 2010Article
- Comparative analysis of chromatin binding by Sex Comb on Midleg (SCM) and other polycomb group repressors at a Drosophila Hox gene.Molecular and cellular biology · 2010Article
- Mechanisms of polycomb gene silencing: knowns and unknowns.Nature reviews. Molecular cell biology · 2009Review
- Molecular genetic analysis of Suppressor 2 of zeste identifies key functional domains.Genetics · 2009Article
- Polycomb group protein Suppressor 2 of zeste is a functional homolog of Posterior Sex Combs.Molecular and cellular biology · 2009Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
The Extra sex combs (ESC) protein is a Polycomb group (PcG) repressor that is a key noncatalytic subunit in the ESC-Enhancer of zeste [E(Z)] histone methyltransferase complex. Survival of esc homozygotes to adulthood based solely on maternal product and peak ESC expression during embryonic stages indicate that ESC is most critical during early development. In contrast, two other PcG repressors in the same complex, E(Z) and Suppressor of zeste-12 [SU(Z)12], are required throughout development for viability and Hox gene repression. Here we describe a novel fly PcG repressor, called ESC-Like (ESCL), whose biochemical, molecular, and genetic properties can explain the long-standing paradox of ESC dispensability during postembryonic times. Developmental Western blots show that ESCL, which is 60% identical to ESC, is expressed with peak abundance during postembryonic stages. Recombinant complexes containing ESCL in place of ESC can methylate histone H3 with activity levels, and lysine specificity for K27, similar to that of the ESC-containing complex. Coimmunoprecipitations show that ESCL associates with E(Z) in postembryonic cells and chromatin immunoprecipitations show that ESCL tracks closely with E(Z) on Ubx regulatory DNA in wing discs. Furthermore, reduced escl+ dosage enhances esc loss-of-function phenotypes and double RNA interference knockdown of ESC/ESCL in wing disc-derived cells causes Ubx derepression. These results suggest that ESCL and ESC have similar functions in E(Z) methyltransferase complexes but are differentially deployed as development proceeds.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.