ArticleMolecular and cellular biology2006
Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis.
Article in Molecular and cellular biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- PTPN11 in cartilage development, adult homeostasis, and diseases.Bone research · 2025Review
- DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing.Scientific reports · 2024Article
- Plasma exosomal DOK3 reflects immunological states in lung tumor and predicts prognosis of gefitinib treatment.Cancer science · 2022Article
- An Integrated Proteomic Strategy to Identify SHP2 Substrates.Journal of proteome research · 2022Article
- Src Family Tyrosine Kinases in Intestinal Homeostasis, Regeneration and Tumorigenesis.Cancers · 2020Review
- CD5 signalosome coordinates antagonist TCR signals to control the generation of Treg cells induced by foreign antigens.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The right and wrong of DOKing the nuclear receptor.EBioMedicine · 2016Article
- Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer.EBioMedicine · 2016Article
- PAG--a multipurpose transmembrane adaptor protein.Oncogene · 2014Review
- Dok-2 adaptor protein regulates the shear-dependent adhesive function of platelet integrin αIIbβ3 in mice.The Journal of biological chemistry · 2014Article
- Differential polarization of C-terminal Src kinase between naive and antigen-experienced CD8+ T cells.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- DOK2 inhibits EGFR-mutated lung adenocarcinoma.PloS one · 2013Article
- Inactivation of the putative suppressor gene DOK1 by promoter hypermethylation in primary human cancers.International journal of cancer · 2012Article
- Oncogenic signaling by tyrosine kinases of the SRC family in advanced colorectal cancer.American journal of cancer research · 2012Article
- Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer.Molecular oncology · 2011Article
- Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling.Science signaling · 2011Article
- Oncogenic tyrosine kinases target Dok-1 for ubiquitin-mediated proteasomal degradation to promote cell transformation.Molecular and cellular biology · 2011Article
- P2X(7) receptor antagonists display agonist-like effects on cell signaling proteins.Biochimica et biophysica acta · 2011Article
- Differential Regulation of RasGAPs in Cancer.Genes & cancer · 2011Article
- Src family tyrosine kinases-driven colon cancer cell invasion is induced by Csk membrane delocalization.Oncogene · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The Dok adaptor proteins play key regulatory roles in receptor and non-receptor kinase-initiated signaling pathways. Dok-1, the prototype member of this family, negatively regulates cell proliferation elicited by numerous growth factors, including platelet-derived growth factor (PDGF). However, how Dok-1 exerts its negative effect on mitogenesis has remained elusive. Using Dok-1 knockout cells and Dok-1 mutants deficient in binding to specific Dok-1-interacting proteins, we show that Dok-1 interferes with PDGF-stimulated c-myc induction and Ras/mitogen-activated protein kinase (MAPK) activation by tethering different signaling components to the cell membrane. Specifically, Dok-1 attenuates PDGF-elicited c-myc induction by recruiting Csk to active Src kinases, whereupon their activities and consequent c-myc induction are diminished. On the other hand, Dok-1 negatively regulates PDGF-induced MAPK activation by acting on Ras-GAP and at least one other Dok-1-interacting protein. Importantly, we demonstrate that Dok-1's actions on both of these signaling pathways contribute to its inhibitory effect on mitogenesis. Our data suggest a mechanistic basis for the inhibitory effect of Dok-1 on growth factor-induced mitogenesis and its role as a tumor suppressor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.