ArticleBlood2006
Zebrafish G protein gamma2 is required for VEGF signaling during angiogenesis.
Article in Blood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
- Riding a Vascular Time Train to Spatiotemporally Attenuate Thrombosis and Restenosis by Double Presentation of Therapeutic Gas and Biomacromolecules.Exploration (Beijing, China) · 2025Article
- GNG2 inhibits brain metastases from colorectal cancer via PI3K/AKT/mTOR signaling pathway.Scientific reports · 2025Article
- Article
- Genome-Wide Selection Signals Reveal Candidate Genes Associated with Plateau Adaptation in Tibetan Sheep.Animals : an open access journal from MDPI · 2024Article
- Advances in Zebrafish for Diabetes Mellitus with Wound Model.Bioengineering (Basel, Switzerland) · 2023Review
- Effects of vasicine in neuroinflammatory zebrafish model.Bioinformation · 2023Article
- GNG2 acts as a tumor suppressor in breast cancer through stimulating MRAS signaling.Cell death & disease · 2022Article
- Interference with KCNJ2 inhibits proliferation, migration and EMT progression of apillary thyroid carcinoma cells by upregulating GNG2 expression.Molecular medicine reports · 2021Article
- A marine sponge associated fungal metabolite monacolin X suppresses angiogenesis by down regulating VEGFR2 signaling.RSC advances · 2019Article
- Prostaglandin E2 promotes embryonic vascular development and maturation in zebrafish.Biology open · 2019Article
- Rescue of hematopoietic stem/progenitor cells formation in plcg1 zebrafish mutant.Scientific reports · 2019Article
- Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio).Neurotoxicology · 2018Article
- Identification of key pathways and genes in colorectal cancer using bioinformatics analysis.Medical oncology (Northwood, London, England) · 2016Article
- Endothelin-1 Pathway Polymorphisms and Outcomes in Pulmonary Arterial Hypertension.American journal of respiratory and critical care medicine · 2015Article
- Alteration of gene expression profiling including GPR174 and GNG2 is associated with vasovagal syncope.Pediatric cardiology · 2015Article
- GPR126 protein regulates developmental and pathological angiogenesis through modulation of VEGFR2 receptor signaling.The Journal of biological chemistry · 2014Article
- A genome-wide gene-environment interaction analysis for tobacco smoke and lung cancer susceptibility.Carcinogenesis · 2014Article
- Article
- GNG2 inhibits invasion of human malignant melanoma cells with decreased FAK activity.American journal of cancer research · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Vascular endothelial growth factor (VEGF) is a major mediator of pathologic angiogenesis, a process necessary for the formation of new blood vessels to support tumor growth. Historically, VEGF has been thought to signal via receptor tyrosine kinases, which are not typically considered to be G protein dependent. Here, we show that targeted knockdown of the G protein gng2 gene (Ggamma2) blocks the normal angiogenic process in developing zebrafish embryos. Moreover, loss of gng2 function inhibits the ability of VEGF to promote the angiogenic sprouting of blood vessels by attenuating VEGF induced phosphorylation of phospholipase C-gamma1 (PLCgamma1) and serine/threonine kinase (AKT). Collectively, these results demonstrate a novel interaction between Ggamma2- and VEGF-dependent pathways to regulate the angiogenic process in a whole-animal model. Blocking VEGF function using a humanized anti-VEGF antibody has emerged as a promising treatment for colorectal, non-small lung cell, and breast cancers. However, this treatment may cause considerable side effects. Our findings provide a new opportunity for cotargeting G protein- and VEGF-dependent pathways to synergistically block pathologic angiogenesis, which may lead to a safer and more efficacious therapeutic regimen to fight cancer.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.