ArticleJournal of clinical pathology2006
HBV, HCV, and TTV detection by in situ polymerase chain reaction could reveal occult infection in hepatocellular carcinoma: comparison with blood markers.
Article in Journal of clinical pathology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Regulatory polymorphism of CXCL10 rs1439490 in seronegative occult hepatitis C virus infection.World journal of gastroenterology · 2018Trial
- Torque Teno Virus: Lights and Shades.Viruses · 2025Review
- Prevalence and Risk Factors of Occult HCV Infection in the Adult Population of Mexico City.Viruses · 2025Article
- Occult Infection with Hepatitis C Virus: Looking for Clear-Cut Boundaries and Methodological Consensus.Journal of clinical medicine · 2021Review
- Occult HCV Infection: The Current State of Knowledge.Iranian Red Crescent medical journal · 2015Review
- A New Twist to a Chronic HCV Infection: Occult Hepatitis C.Gastroenterology research and practice · 2015Review
- Molecular epidemiology of different hepatitis C genotypes in serum and peripheral blood mononuclear cells in jahrom city of iran.Hepatitis monthly · 2014Article
- Seronegative hepatitis C virus infection.Archivum immunologiae et therapiae experimentalis · 2014Review
- Occult hepatitis C virus infection in candidates for liver transplant with cryptogenic cirrhosis.Hepatitis monthly · 2013Article
- New perspectives in occult hepatitis C virus infection.World journal of gastroenterology · 2012Article
- Occult HCV infection: an unexpected finding in a population unselected for hepatic disease.PloS one · 2009Article
- Does occult hepatitis C virus infection exist?Journal of clinical microbiology · 2008Article
- Occult hepatitis C virus infection: a new form of hepatitis C.World journal of gastroenterology · 2006Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo report a retrospective analysis on the presence of hepatitis B virus (HBV), hepatitis C virus (HCV), and transfusion transmitted virus (TTV) sequences in formalin fixed, paraffin embedded liver biopsies from eight patients with hepatocellular carcinoma, in comparison with blood markers.
methodsA direct in situ polymerase chain reaction (PCR) technique was developed for the detection and localisation of genomic signals in the liver tissue. Conventional serological and molecular methods were used for blood evaluation.
resultsIn situ PCR showed the presence of one of the three viruses (four HCV, two HBV, and one TTV) in seven of the eight patients. In addition, a co-infection with HBV and HCV was detected in one patient. HCV and HBV sequences were located in the cytoplasm and the nucleus, respectively. When compared with blood markers, these findings were compatible with one occult HBV and two occult HCV infections.
conclusionsThese findings provide further evidence for occult HBV and HCV infections in cancerous tissues from patients with hepatocellular carcinomas. In situ PCR could be an additional tool for evaluating the viral aetiology of hepatocellular carcinoma alongside conventional diagnostic procedures.
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