ArticleJournal of virology2006
Human chromosome 2 carries a gene required for production of infectious human immunodeficiency virus type 1.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Development of an efficient reproducible cell-cell transmission assay for rapid quantification of SARS-CoV-2 spike interaction with hACE2.Cell reports methods · 2022Article
- Article
- Human CRM1 augments production of infectious human and feline immunodeficiency viruses from murine cells.Journal of virology · 2012Article
- Transmembrane protein aptamers that inhibit CCR5 expression and HIV coreceptor function.Journal of virology · 2012Article
- Evolution of a species-specific determinant within human CRM1 that regulates the post-transcriptional phases of HIV-1 replication.PLoS pathogens · 2011Article
- High natural permissivity of primary rabbit cells for HIV-1, with a virion infectivity defect in macrophages as the final replication barrier.Journal of virology · 2010Article
- Endogenous CD317/Tetherin limits replication of HIV-1 and murine leukemia virus in rodent cells and is resistant to antagonists from primate viruses.Journal of virology · 2010Article
- SRp40 and SRp55 promote the translation of unspliced human immunodeficiency virus type 1 RNA.Journal of virology · 2010Article
- Productive replication of Vif-chimeric HIV-1 in feline cells.Journal of virology · 2010Article
- Article
- Inability of human immunodeficiency virus type 1 produced in murine cells to selectively incorporate primer formula.Journal of virology · 2008Article
- Mouse T-cells restrict replication of human immunodeficiency virus at the level of integration.Retrovirology · 2008Article
- Relief of preintegration inhibition and characterization of additional blocks for HIV replication in primary mouse T cells.PloS one · 2008Article
- Isolation and characterization of mouse-human microcell hybrid cell clones permissive for infectious HIV particle release.Virology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human immunodeficiency virus type 1 (HIV) replicates only in certain primate cells. In murine cells expressing cyclin T1, a posttranscriptional block exists such that small amounts of capsid and little infectious virus are released. This block is relieved in part by fusion with human cells. Here we have tested a panel of mouse-human somatic cell hybrids for production of infectious virus. Only those containing human chromosome 2 were permissive, which correlated with capsid production. The effect was specific to HIV in that release of murine leukemia virus was minimally affected by the presence of chromosome 2. Although expression of Vpu markedly increased capsid production in the absence of chromosome 2, it did not result in a corresponding increase in infectious HIV. The presence of chromosome 2 did not have consistent effects on the amount of unspliced viral RNA, whereas the amount of cell-associated Gag p55 was increased a fewfold. These results suggest that processing of HIV Gag can be corrected by one or more genes present on human chromosome 2 to allow production of infectious HIV from murine cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.