ArticleThe Journal of biological chemistry2006
Identification of T-cadherin as a novel target of DNA methyltransferase 3B and its role in the suppression of nerve growth factor-mediated neurite outgrowth in PC12 cells.
Article in The Journal of biological chemistry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- T-cadherin as a potential novel regulator of intestinal inflammation and fibrosis.Frontiers in physiology · 2026Review
- The miR-23a/27a/24-2 cluster promotes postoperative progression of early-stage non-small cell lung cancer.Molecular therapy oncolytics · 2022Article
- Transcriptional and Epigenetic Regulation in Injury-Mediated Neuronal Dendritic Plasticity.Neuroscience bulletin · 2017Review
- Cadherin-13 Deficiency Increases Dorsal Raphe 5-HT Neuron Density and Prefrontal Cortex Innervation in the Mouse Brain.Frontiers in cellular neuroscience · 2017Article
- Cadherin-13, a risk gene for ADHD and comorbid disorders, impacts GABAergic function in hippocampus and cognition.Translational psychiatry · 2015Article
- Aberrant expression and localization of deoxyribonucleic acid methyltransferase 3B in endometriotic stromal cells.Fertility and sterility · 2015Article
- Regulation of human RNA polymerase III transcription by DNMT1 and DNMT3a DNA methyltransferases.The Journal of biological chemistry · 2012Article
- Epigenetic regulation of axon and dendrite growth.Frontiers in molecular neuroscience · 2012Article
- A theoretical molecular network for dyslexia: integrating available genetic findings.Molecular psychiatry · 2011Review
- HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors.PloS one · 2010Article
- T-cadherin structures reveal a novel adhesive binding mechanism.Nature structural & molecular biology · 2010Article
- The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex.Cerebellum (London, England) · 2009Article
- A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation.Cancer research · 2009Article
- Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis.Cancer research · 2008Article
- ICF, an immunodeficiency syndrome: DNA methyltransferase 3B involvement, chromosome anomalies, and gene dysregulation.Autoimmunity · 2008Review
- A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression.Analytical biochemistry · 2008Article
- NGF/PI3K signaling-mediated epigenetic regulation of delta opioid receptor gene expression.Biochemical and biophysical research communications · 2008Article
- Treatment of PC12 cells with nerve growth factor induces proteasomal degradation of T-cadherin that requires tyrosine phosphorylation of its cadherin domain.The Journal of biological chemistry · 2007Article
- Adiponectin receptors, with special focus on the role of the third receptor, T-cadherin, in vascular disease.Medical molecular morphology · 2007Review
Corrections and comments
- Retraction · 2018-02-13Concerns/Issues about Image · Unreliable Image ·
- Retracted
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Previously we showed that DNA methyltransferase 3b (Dnmt3b) is required for nerve growth factor (NGF)-induced differentiation of PC12 cells to neuronal phenotype. The present study identified T-cadherin (T-Cad) as one of the targets of Dnmt3b by chromatin immunoprecipitation (ChIP) assay. Combined bisulfite restriction analysis and bisulfite sequencing showed that T-Cad promoter was sparsely methylated in PC12 cells. ChIP-CHOP analysis demonstrated that Dnmt3b is associated with T-Cad promoter irrespective of its methylation status. The mRNA and protein levels of T-Cad were markedly elevated in cells depleted of Dnmt3b by antisense or small interfering RNA. Suppression of T-Cad promoter activity by Dnmt3b was independent of its catalytic activity, which was consistent with the insignificant change in T-Cad promoter methylation status in Dnmt3b-depleted cells. In contrast, deletion of its N-terminal ATRX and PWWP domain abolished its repressor function. Association of histone deacetylase 2 (Hdac2) with T-Cad promoter and restoration of the promoter activity from Dnmt3b-mediated suppression upon treatment with Hdac inhibitor indicated involvement of histone deacetylation in this process. NGF-induced neurite outgrowth was inhibited in a dose dependent manner upon ectopic expression of T-Cad in PC12 cells. Immunofluorescence studies showed that T-Cad was redistributed upon NGF treatment, as evident from its concentration in axon growth cones as opposed to its localization at cell-cell contact region in undifferentiated cells. These results demonstrate a novel role of T-Cad in the NGF-mediated differentiation of PC12 cells to neuronal phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.