ArticleProceedings of the National Academy of Sciences of the United States of America2006
Linkage analysis of quantitative traits for obesity, diabetes, hypertension, and dyslipidemia on the island of Kosrae, Federated States of Micronesia.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Prevention and treatment of pediatric obesity: an endocrine society clinical practice guideline based on expert opinion.The Journal of clinical endocrinology and metabolism · 2008Guideline
- Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.Arteriosclerosis, thrombosis, and vascular biology · 2008Pooled it
- Analysis of the genetic basis of height in large Jewish nuclear families.PLoS genetics · 2019Article
- Autophagy as an emerging target in cardiorenal metabolic disease: From pathophysiology to management.Pharmacology & therapeutics · 2018Review
- Wild-derived mice: from genetic diversity to variation in immune responses.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Do You Want to Ditch Sodium? Meet Nitric Oxide Synthase 1β at the Macula Densa.Journal of the American Society of Nephrology : JASN · 2016Article
- Genome-wide association study identifies African-ancestry specific variants for metabolic syndrome.Molecular genetics and metabolism · 2015Article
- Article
- A Copy Number Variant on Chromosome 20q13.3 Implicated in Thinness and Severe Obesity.Journal of obesity · 2015Article
- Autophagy--a key player in cellular and body metabolism.Nature reviews. Endocrinology · 2014Review
- Hypothesis of the neuroendocrine cortisol pathway gene role in the comorbidity of depression, type 2 diabetes, and metabolic syndrome.The application of clinical genetics · 2014Review
- Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.Cell · 2013Article
- Low-pass genome-wide sequencing and variant inference using identity-by-descent in an isolated human population.Genetics · 2012Article
- Genetic copy number variants in myocardial infarction patients with hyperlipidemia.BMC genomics · 2011Article
- Hypercholesterolemia and a candidate gene within the 12q24 locus.Cardiovascular diabetology · 2011Article
- Modifier locus of the skeletal muscle involvement in Emery-Dreifuss muscular dystrophy.Human genetics · 2011Article
- Linkage analysis of adult height in a large pedigree from a Dutch genetically isolated population.Human genetics · 2009Article
- Systematic haplotype analysis resolves a complex plasma plant sterol locus on the Micronesian Island of Kosrae.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute Family Heart Study.Hypertension (Dallas, Tex. : 1979) · 2009Article
- Whole population, genome-wide mapping of hidden relatedness.Genome research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
Obesity, diabetes, hypertension, and heart disease are highly heritable conditions that in aggregate are the major causes of morbidity and mortality in the developed world and are growing problems in developing countries. To map the causal genes, we conducted a population screen for these conditions on the Pacific Island of Kosrae. Family history and genetic data were used to construct a pedigree for the island. Analysis of the pedigree showed highly significant heritability for the metabolic traits under study. DNA samples from 2,188 participants were genotyped with 405 microsatellite markers with an average intermarker distance of 11 cM. A protocol using loki, a Markov chain Monte Carlo sampling method, was developed to analyze the Kosraen pedigree for height, a model quantitative trait. Robust quantitative trait loci for height were found on 10q21 and 1p31. This protocol was used to map a set of metabolic traits, including plasma leptin to chromosome region 5q35; systolic blood pressure to 20p12; total cholesterol to 19p13, 12q24, and 16qter; hip circumference to 10q25 and 4q23; body mass index to 18p11 and 20q13; apolipoprotein B to 2p24-25; weight to 18q21; and fasting blood sugar to 1q31-1q43. Several of these same chromosomal regions have been identified in previous studies validating the use of loki. These studies add information about the genetics of the metabolic syndrome and establish an analytical approach for linkage analysis of complex pedigrees. These results also lay the foundation for whole genome scans with dense sets of SNPs aimed to identifying causal genes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.