ArticleProceedings of the National Academy of Sciences of the United States of America2006
Role of the lytic repressor in prophage induction of phage lambda as analyzed by a module-replacement approach.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
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- Urinary bacteriophage cooperation with bacterial pathogens during human urinary tract infections supports lysogenic phage therapy.Communications biology · 2025Article
- Liver X Receptor-Inducible Host E3 Ligase IDOL Targets a Human Cytomegalovirus Reactivation Determinant.Journal of virology · 2023Article
- Control of λ LysogenicACS synthetic biology · 2022Article
- RNA polymerase efficiently transcribes through DNA-scaffolded, cooperative bacteriophage repressor complexes.FEBS letters · 2022Article
- Gradients in gene essentiality reshape antibacterial research.FEMS microbiology reviews · 2022Review
- Characterization of a T4-like Bacteriophage vB_EcoM-Sa45lw as a Potential Biocontrol Agent for Shiga Toxin-Producing Escherichia coli O45 Contaminated on Mung Bean Seeds.Microbiology spectrum · 2022Article
- Characterization of the genetic switch from phage ɸ13 important for Staphylococcus aureus colonization in humans.MicrobiologyOpen · 2021Article
- Spinal Cord Injury Changes the Structure and Functional Potential of Gut Bacterial and Viral Communities.mSystems · 2021Article
- YMC-2011, a Temperate Phage of Streptococcus salivarius 57.I.Applied and environmental microbiology · 2017Article
- Evolution of genetic switch complexity.Bacteriophage · 2013Article
- The effect of nonspecific binding of lambda repressor on DNA looping dynamics.Biophysical journal · 2012Article
- Effects of macromolecular crowding on genetic networks.Biophysical journal · 2011Article
- Decision making in living cells: lessons from a simple system.Annual review of biophysics · 2011Review
- Lysogen stability is determined by the frequency of activity bursts from the fate-determining gene.Molecular systems biology · 2010Article
- Stability and instability in the lysogenic state of phage lambda.Journal of bacteriology · 2010Article
- Predicting gene-regulation functions: lessons from temperate bacteriophages.Biophysical journal · 2010Article
- Review
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Using a module exchange approach, we have tested a long-standing model for the role of Cro repressor in lambda prophage induction. This epigenetic switch from lysogeny to the lytic state occurs on activation of the host SOS system, which leads to specific cleavage of CI repressor. It has been proposed that Cro repressor, which operates during lytic growth and which we shall term the lytic repressor, is crucial to prophage induction. In this view, Cro binds to the O(R)3 operator, thereby repressing the cI gene and making the switch irreversible. Here we tested this model by replacing lambda Cro with a dimeric form of Lac repressor and adding several lac operators. This approach allowed us to regulate the function of the lytic repressor at will and to prevent it from repressing cI, because lac repressor could not repress P(RM) in our constructs. Repression of cI by the lytic repressor was not required for prophage induction to occur. However, our evidence suggests that this binding can make induction more efficient, particularly at intermediate levels of DNA damage that otherwise cause induction of only a fraction of the population. These results indicate that this strategy of module exchange will have broad applications for analysis of gene regulatory circuits.
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