ArticleJournal of the American Chemical Society2006
Chain packing in the inverted hexagonal phase of phospholipids: a study by X-ray anomalous diffraction on bromine-labeled chains.
Article in Journal of the American Chemical Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 38 citations in OpenAlex.
- Article
- Interaction of a short antimicrobial peptide on charged lipid bilayer: A case study on aurein 1.2 peptide.BBA advances · 2022Article
- Review
- Rhombohedral trap for studying molecular oligomerization in membranes: application to daptomycin.Soft matter · 2019Article
- Effect of Cholesterol on the Structure of a Five-Component Mitochondria-Like Phospholipid Membrane.Membranes · 2015Article
- Process of inducing pores in membranes by melittin.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Importance of the hexagonal lipid phase in biological membrane organization.Frontiers in plant science · 2013Article
- Acyl-chain correlation in membrane fusion intermediates: x-ray diffraction from the rhombohedral lipid phase.Biophysical journal · 2012Article
- A novel phase of compressed bilayers that models the prestalk transition state of membrane fusion.Biophysical journal · 2012Article
- Structure of transmembrane pore induced by Bax-derived peptide: evidence for lipidic pores.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Interplay of unsaturated phospholipids and cholesterol in membranes: effect of the double-bond position.Biophysical journal · 2008Article
- Structure of the alamethicin pore reconstructed by x-ray diffraction analysis.Biophysical journal · 2008Article
- The condensing effect of cholesterol in lipid bilayers.Biophysical journal · 2007Article
- Evidence of cholesterol accumulated in high curvature regions: implication to the curvature elastic energy for lipid mixtures.Biophysical journal · 2007Article
- Method of x-ray anomalous diffraction for lipid structures.Biophysical journal · 2006Article
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5 authors at 1 institution in 1 country.
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Abstract
Although lipid phases are routinely studied by X-ray diffraction, construction of their unit cell structures from the diffraction data is difficult except for the lamellar phases. This is due to the well-known phase problem of X-ray diffraction. Here we successfully applied the multiwavelength anomalous dispersion (MAD) method to solve the phase problem for an inverted hexagonal phase of a phospholipid with brominated chains. Although the principle of the MAD method for all systems is the same, we found that for lipid structures it is necessary to use a procedure of analysis significantly different from that used for protein crystals. The inverted hexagonal phase has been used to study the chain packing in a hydrophobic interstice where three monolayers meet. Hydrophobic interstices are of great interest, because they occur in the intermediate states of membrane fusion. It is generally believed that chain packing in such a region is energy costly. Consequently, it has been speculated that the inverted lipid tube is likely to deviate from a circular shape, and the chain density distribution might be nonuniform. The bromine distribution obtained from the MAD analysis provides the information for the chain packing in the hexagonal unit cell. The intensity of the bromine distribution is undulated around the unit cell. The analysis shows that the lipid chains pack the hexagonal unit cell at constant volume per chain, with no detectable effect from a high-energy interstitial region.
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