ArticleWorld journal of gastroenterology2006
Identification of differently expressed genes in human colorectal adenocarcinoma.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 18 citations in OpenAlex.
- hcrcn81 promotes cell proliferation through Wnt signaling pathway in colorectal cancer.Medical oncology (Northwood, London, England) · 2016Article
- The Key Role of Calmodulin in KRAS-Driven Adenocarcinomas.Molecular cancer research : MCR · 2015Review
- The role of c2orf68 and PI3K/Akt/mTOR pathway in human colorectal cancer.Medical oncology (Northwood, London, England) · 2014Article
- Involvement of SET in the Wnt signaling pathway and the development of human colorectal cancer.Oncology letters · 2014Article
- Expression ofBiomedical reports · 2013Article
- Expression of the newly identified gene CAC1 in the hippocampus of Alzheimer's disease patients.Journal of molecular neuroscience : MN · 2012Article
- SOX9 expression and its methylation status in gastric cancer.Virchows Archiv : an international journal of pathology · 2012Article
- Bioinformatics Analysis and Validation of the Expressed Sequences Tag in Human Colorectal Adenocarcinoma.Gastroenterology research · 2009Article
- Protein alterations in infiltrating ductal carcinomas of the breast as detected by nonequilibrium pH gradient electrophoresis and mass spectrometry.Journal of biomedicine & biotechnology · 2008Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the differently expressed genes in human colorectal adenocarcinoma.
methodsThe integrated approach for gene expression profiling that couples suppression subtractive hybridization, high-throughput cDNA array, sequencing, bioinformatics analysis, and reverse transcriptase real-time quantitative polymerase chain reaction (PCR) was carried out. A set of cDNA clones including 1260 SSH inserts amplified by PCR was arrayed using robotic printing. The cDNA arrays were hybridized with fluorescent-labeled probes prepared from RNA of human colorectal adenocarcinoma (HCRAC) and normal colorectal tissues.
resultsA total of 86 genes were identified, 16 unknown genes and 70 known genes. The transcription factor Somult9 influencing cell differentiation was downregulated. At the same time, Heat shock protein 10 KDis downregulated and Calmoulin is up-regulated.
conclusionDownregulation of heat shock protein 10 KD lost its inhibition of Ras, and then attenuated the Ras GTPase signaling pathway, increased cell proliferation and inhibited cell apoptosis. Down-regulated transcription factor Somult9 influences cell differentiation and cell-specific gene expression. Down-regulated Somult9 also decreases its binding to calmodulin, accumulates calmodulin as receptor-activated kinase and phosphorylase kinase due to the activation of PhK.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.