ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2006
Basic helix-loop-helix gene Hes6 delineates the sensory hair cell lineage in the inner ear.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Recent advances in understanding the role of HES6 in cancers.Theranostics · 2022Review
- Molecular Pathways Modulating Sensory Hair Cell Regeneration in Adult Mammalian Cochleae: Progress and Perspectives.International journal of molecular sciences · 2021Review
- Generation of inner ear hair cells by direct lineage conversion of primary somatic cells.eLife · 2020Article
- Transcriptomes of cochlear inner and outer hair cells from adult mice.Scientific data · 2018Article
- Hairy and Enhancer of Split 6 (Hes6) Deficiency in Mouse Impairs Neuroblast Differentiation in Dentate Gyrus Without Affecting Cell Proliferation and Integration into Mature Neurons.Cellular and molecular neurobiology · 2016Article
- SoxC transcription factors are essential for the development of the inner ear.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Single-cell RNA-Seq resolves cellular complexity in sensory organs from the neonatal inner ear.Nature communications · 2015Article
- Characterization of the transcriptome of nascent hair cells and identification of direct targets of the Atoh1 transcription factor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The transcriptome of utricle hair cell regeneration in the avian inner ear.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear.Developmental biology · 2013Article
- Atoh1, an essential transcription factor in neurogenesis and intestinal and inner ear development: function, regulation, and context dependency.Journal of the Association for Research in Otolaryngology : JARO · 2012Review
- Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational research.Hearing research · 2011Review
- Global gene expression reveals a set of new genes involved in the modification of cells during erythroid differentiation.Cell proliferation · 2010Article
- Identification of differentially expressed genes in early inner ear development.Gene expression patterns : GEP · 2010Article
- Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development.BMC developmental biology · 2008Article
- bHLH-Orange Transcription Factors in Development and Cancer.Translational oncogenomics · 2007Article
- The molecular basis of neurosensory cell formation in ear development: a blueprint for hair cell and sensory neuron regeneration?BioEssays : news and reviews in molecular, cellular and developmental biology · 2006Review
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7 authors at 3 institutions in 2 countries.
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Abstract
The basic helix-loop-helix (bHLH) gene Hes6 is known to promote neural differentiation in vitro. Here, we report the expression and functional studies of Hes6 in the inner ear. The expression of Hes6 appears to be parallel to that of Math1 (also known as Atoh1), a bHLH gene necessary and sufficient for hair cell differentiation. Hes6 is expressed initially in the presumptive hair cell precursors in the cochlea. Subsequently, the expression of Hes6 is restricted to morphologically differentiated hair cells. Similarly, the expression of Hes6 in the vestibule is in the hair cell lineage. Hes6 is dispensable for hair cell differentiation, and its expression in inner ear hair cells is abolished in the Math1-null animals. Furthermore, the introduction of Hes6 into the cochlea in vitro is not sufficient to promote sensory or neuronal differentiation. Therefore, Hes6 is downstream of Math1 and its expression in the inner ear delineates the sensory lineage. However, the role of Hes6 in the inner ear remains elusive.
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