ArticleNeurology2006
Memory fMRI in left hippocampal sclerosis: optimizing the approach to predicting postsurgical memory.
Article in Neurology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 129 citations in OpenAlex.
- Exploring transient global amnesia: a 14-year retrospective study of 142 cases.BMJ neurology open · 2026Article
- Analysis of brain volume in hippocampal sclerotic temporal lobe epilepsy using automatic brain segmentation technology.Quantitative imaging in medicine and surgery · 2025Article
- A Comprehensive Review of Recent Trends in Surgical Approaches for Epilepsy Management.Cureus · 2024Review
- Computational support, not primacy, distinguishes compensatory memory reorganization in epilepsy.Brain communications · 2021Article
- Establishing a Developmentally Appropriate fMRI Paradigm Relevant to Presurgical Mapping of Memory in Children.Brain topography · 2020Article
- Emotional oddball: A review on memory effects.Psychonomic bulletin & review · 2019Review
- Comparing the Wada Test and Functional MRI for the Presurgical Evaluation of Memory in Temporal Lobe Epilepsy.Current neurology and neuroscience reports · 2019Review
- Imaging episodic memory during development and childhood epilepsy.Journal of neurodevelopmental disorders · 2018Review
- A Functional MRI-Based Model for Individual Memory Assessment in Patients Eligible for Anterior Temporal Lobe Resection.The open neuroimaging journal · 2017Article
- The Parahippocampal Cortex Mediates Contextual Associative Memory: Evidence from an fMRI Study.BioMed research international · 2016Article
- Article
- Bringing memory fMRI to the clinic: comparison of seven memory fMRI protocols in temporal lobe epilepsy.Human brain mapping · 2015Article
- Functional and structural correlates of memory in patients with mesial temporal lobe epilepsy.Frontiers in neurology · 2015Article
- Functional neuro-imaging as a pre-surgical tool in epilepsy.Annals of Indian Academy of Neurology · 2014Article
- Hemispheric lateralization interrupted: material-specific memory deficits in temporal lobe epilepsy.Frontiers in human neuroscience · 2013Review
- A functional magnetic resonance imaging study mapping the episodic memory encoding network in temporal lobe epilepsy.Brain : a journal of neurology · 2013Article
- Neuropsychology in temporal lobe epilepsy: influences from cognitive neuroscience and functional neuroimaging.Epilepsy research and treatment · 2012Article
- Role of functional MRI in presurgical evaluation of memory function in temporal lobe epilepsy.Epilepsy research and treatment · 2012Article
- Network interactions explain effective encoding in the context of medial temporal damage in MCI.Human brain mapping · 2011Article
- Preoperative prediction of verbal episodic memory outcome using FMRI.Neurosurgery clinics of North America · 2011Review
Corrections and comments
- Commented on by
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAn optimal technique for clinical memory fMRI is not established. Previous studies suggest activity in right parahippocampal gyrus and right hippocampus shows the strongest difference between left hippocampal sclerosis (HS) patients and normal control subjects and that the difference in activity between left and right hippocampus predicts postoperative memory change.
methodsThe authors studied 30 patients with mesial temporal lobe epilepsy (mTLE) and left HS, 12 of whom subsequently underwent surgery, and 13 normal control subjects. The patients who had surgery underwent neuropsychometric evaluation pre- and postoperatively. All subjects underwent a verbal memory encoding event-related fMRI study. Activation maps were assessed visually. Subsequently, the brain regions involved in the memory task were revealed by group averaging; these regions were used to determine regions of interest (ROIs) for subsequent analysis. By use of stepwise discriminant function and stepwise multiple regression, the ROIs that optimally discriminated between patients and normal control subjects and that optimally predicted postoperative verbal memory outcome were determined.
resultsVisual inspection of individual patient activation statistic maps revealed noisy data that did not afford visual interpretation. Stepwise discriminant function revealed the difference between left and right hippocampal activity best discriminated between patients and normal control subjects. Stepwise multiple regression revealed left hippocampal activity was the strongest predictor of postoperative verbal memory outcome; greater left hippocampal activity predicted a greater postoperative decline in memory.
conclusionsPatients with left hippocampal sclerosis (HS) differ from normal control subjects in the distribution of memory-encoding activity between left and right hippocampus. Functional adequacy of left hippocampus best predicts postoperative memory outcome in left HS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.