ArticleBiophysical journal2006
Analysis of puff dynamics in oocytes: interdependence of puff amplitude and interpuff interval.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Biological physics to uncover cell signaling.Biophysical reviews · 2025Review
- Modeling IPBiophysical journal · 2023Article
- Changes in CaFrontiers in physiology · 2019Article
- Mapping Interpuff Interval Distribution to the Properties of Inositol Trisphosphate Receptors.Biophysical journal · 2017Article
- Article
- Basis for a neuronal version of Grover's quantum algorithm.Frontiers in molecular neuroscience · 2014Article
- Factors determining the recruitment of inositol trisphosphate receptor channels during calcium puffs.Biophysical journal · 2013Article
- A stochastic model of calcium puffs based on single-channel data.Biophysical journal · 2013Article
- Termination of Ca²+ release for clustered IP₃R channels.PLoS computational biology · 2012Article
- The probability of triggering calcium puffs is linearly related to the number of inositol trisphosphate receptors in a cluster.Biophysical journal · 2012Article
- Intracellular calcium signals display an avalanche-like behavior over multiple lengthscales.Frontiers in physiology · 2012Article
- Calcium oscillations.Cold Spring Harbor perspectives in biology · 2011Review
- Mean field strategies induce unrealistic non-linearities in calcium puffs.Frontiers in physiology · 2011Article
- Article
- Intra-cluster percolation of calcium signals.PloS one · 2010Article
- Regulation of IP(3)R Channel Gating by Ca(2+) and Ca(2+) Binding Proteins.Current topics in membranes · 2010Article
- A simple sequential-binding model for calcium puffs.Chaos (Woodbury, N.Y.) · 2009Article
- Imaging the quantal substructure of single IP3R channel activity during Ca2+ puffs in intact mammalian cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Rapid ligand-regulated gating kinetics of single inositol 1,4,5-trisphosphate receptor Ca2+ release channels.EMBO reports · 2007Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Puffs are localized Ca(2+) signals that arise in oocytes in response to inositol 1,4,5-trisphosphate (IP(3)). They are analogous to the sparks of myocytes and are believed to be the result of the liberation of Ca(2+) from the endoplasmic reticulum through the coordinated opening of IP(3) receptor/channels clustered at a functional release site. In this article, we analyze sequences of puffs that occur at the same site to help elucidate the mechanisms underlying puff dynamics. In particular, we show a dependence of the interpuff time on the amplitude of the preceding puff, and of the amplitude of the following puff on the preceding interval. These relationships can be accounted for by an inhibitory role of the Ca(2+) that is liberated during puffs. We construct a stochastic model for a cluster of IP(3) receptor/channels that quantitatively replicates the observed behavior, and we determine that the characteristic time for a channel to escape from the inhibitory state is of the order of seconds.
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