ArticleBMC genomics2006
Identification of rat lung--prominent genes by a parallel DNA microarray hybridization.
Article in BMC genomics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 23 citations in OpenAlex.
- Regulation of myofibroblast differentiation by miR-424 during epithelial-to-mesenchymal transition.Archives of biochemistry and biophysics · 2015Article
- MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome.BMC medical genomics · 2014Article
- Identification of microRNAs changed in the neonatal lungs in response to hyperoxia exposure.Physiological genomics · 2012Article
- Hoxd11 specifies a program of metanephric kidney development within the intermediate mesoderm of the mouse embryo.Developmental biology · 2008Article
- Annexin A2 interactions with Rab14 in alveolar type II cells.The Journal of biological chemistry · 2008Article
- Arsenic-induced changes in the gene expression of lung epithelial L2 cells: implications in carcinogenesis.BMC genomics · 2008Article
- Identification of rat lung-specific microRNAs by micoRNA microarray: valuable discoveries for the facilitation of lung research.BMC genomics · 2007Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe comparison of organ transcriptomes is an important strategy for understanding gene functions. In the present study, we attempted to identify lung-prominent genes by comparing the normal transcriptomes of rat lung, heart, kidney, liver, spleen, and brain. To increase the efficiency and reproducibility, we first developed a novel parallel hybridization system, in which 6 samples could be hybridized onto a single slide at the same time.
resultsWe identified the genes prominently expressed in the lung (147) or co-expressed in lung-heart (23), lung-liver (37), lung-spleen (203), and lung-kidney (98). The known functions of the lung-prominent genes mainly fell into 5 categories: ligand binding, signal transducer, cell communication, development, and metabolism. Real-time PCR confirmed 13 lung-prominent genes, including 5 genes that have not been investigated in the lung, vitamin D-dependent calcium binding protein (Calb3), mitogen activated protein kinase 13 (Mapk13), solute carrier family 29 transporters, member 1 (Slc29a1), corticotropin releasing hormone receptor (Crhr1), and lipocalin 2 (Lcn2).
conclusionThe lung-prominent genes identified in this study may provide an important clue for further investigation of pulmonary functions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.