ArticleChromosoma2006
Meiotic recombination proteins localize to linear elements in Schizosaccharomyces pombe.
Article in Chromosoma, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- The proper interplay between the expression of Spo11 splice isoforms and the structure of the pseudoautosomal region promotes XY chromosomes recombination.Cellular and molecular life sciences : CMLS · 2023Article
- The RNA-binding protein FUS/TLS interacts with SPO11 and PRDM9 and localize at meiotic recombination hotspots.Cellular and molecular life sciences : CMLS · 2023Article
- Meiotic chromosome organization and its role in recombination and cancer.Current topics in developmental biology · 2023Review
- Rec8 Cohesin-mediated Axis-loop chromatin architecture is required for meiotic recombination.Nucleic acids research · 2022Article
- Dynamic configurations of meiotic DNA-break hotspot determinant proteins.Journal of cell science · 2022Article
- Redirecting meiotic DNA break hotspot determinant proteins alters localized spatial control of DNA break formation and repair.Nucleic acids research · 2022Article
- Linear elements are stable structures along the chromosome axis in fission yeast meiosis.Chromosoma · 2021Article
- Article
- Catalase T-Deficient Fission Yeast Meiocytes Show Resistance to Ionizing Radiation.Antioxidants (Basel, Switzerland) · 2020Article
- Intragenic meiotic recombination in Schizosaccharomyces pombe is sensitive to environmental temperature changes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2020Article
- Advances Towards How Meiotic Recombination Is Initiated: A Comparative View and Perspectives for Plant Meiosis Research.International journal of molecular sciences · 2019Review
- Mouse REC114 is essential for meiotic DNA double-strand break formation and forms a complex with MEI4.Life science alliance · 2018Article
- The conserved histone variant H2A.Z illuminates meiotic recombination initiation.Current genetics · 2018Review
- Genetic interactions between the chromosome axis-associated protein Hop1 and homologous recombination determinants in Schizosaccharomyces pombe.Current genetics · 2018Article
- The histone variant H2A.Z promotes initiation of meiotic recombination in fission yeast.Nucleic acids research · 2018Article
- Functional organization of protein determinants of meiotic DNA break hotspots.Scientific reports · 2017Article
- Meiotic DNA break formation requires the unsynapsed chromosome axis-binding protein IHO1 (CCDC36) in mice.Nature cell biology · 2016Article
- Dbl2 Regulates Rad51 and DNA Joint Molecule Metabolism to Ensure Proper Meiotic Chromosome Segregation.PLoS genetics · 2016Article
- Meiotic chromosome mobility in fission yeast is resistant to environmental stress.Scientific reports · 2016Article
- MEI4 – a central player in the regulation of meiotic DNA double-strand break formation in the mouse.Journal of cell science · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In fission yeast, meiotic prophase nuclei develop structures known as linear elements (LinEs), instead of a canonical synaptonemal complex. LinEs contain Rec10 protein. While Rec10 is essential for meiotic recombination, the precise role of LinEs in this process is unknown. Using in situ immunostaining, we show that Rec7 (which is required for meiosis-specific DNA double-strand break (DSB) formation) aggregates in foci on LinEs. The strand exchange protein Rad51, which is known to mark the sites of DSBs, also localizes to LinEs, although to a lesser degree. The number of Rec7 foci corresponds well with the average number of genetic recombination events per meiosis suggesting that Rec7 marks the sites of recombination. Rec7 and Rad51 foci do not co-localize, presumably because they act sequentially on recombination sites. The localization of Rec7 is dependent on Rec10 but independent of the DSB-inducing protein Rec12/Spo11. Neither Rec7 nor Rad51 localization depends on the LinE-associated proteins Hop1 and Mek1, but the formation of Rad51 foci depends on Rec10, Rec7, and, as expected, Rec12/Spo11. We propose that LinEs form around designated recombination sites before the induction of DSBs and that most, if not all, meiotic recombination initiates within the setting provided by LinEs.
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