ArticleExperimental eye research2006
Nok plays an essential role in maintaining the integrity of the outer nuclear layer in the zebrafish retina.
Article in Experimental eye research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 41 citations in OpenAlex.
- Effect of Dync1h1 on Phototransduction Protein Transport and the Development and Maintenance of Photoreceptor Cells in Zebrafish.Investigative ophthalmology & visual science · 2025Article
- The Roles of Par3, Par6, and aPKC Polarity Proteins in Normal Neurodevelopment and in Neurodegenerative and Neuropsychiatric Disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Review
- Rapamycin relieves the cataract caused by ablation of Gja8b through stimulating autophagy in zebrafish.Autophagy · 2021Article
- Zebrafish Crb1, Localizing Uniquely to the Cell Membranes around Cone Photoreceptor Axonemes, Alleviates Light Damage to Photoreceptors and Modulates Cones' Light Responsiveness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
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- Self-organising aggregates of zebrafish retinal cells for investigating mechanisms of neural lamination.Development (Cambridge, England) · 2017Article
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- Zebrafish methanol exposure causes patterning defects and suppressive cell proliferation in retina.American journal of translational research · 2017Article
- Expression patterns of zebrafishMolecular vision · 2017Article
- Patterning the cone mosaic array in zebrafish retina requires specification of ultraviolet-sensitive cones.PloS one · 2014Article
- The cone-dominant retina and the inner ear of zebrafish express the ortholog of CLRN1, the causative gene of human Usher syndrome type 3A.Gene expression patterns : GEP · 2013Article
- Spatial-temporal expressions of Crumbs and Nagie oko and their interdependence in zebrafish central nervous system during early development.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013Article
- Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis.Human molecular genetics · 2012Article
- Crb apical polarity proteins maintain zebrafish retinal cone mosaics via intercellular binding of their extracellular domains.Developmental cell · 2012Article
- Coupling mechanical deformations and planar cell polarity to create regular patterns in the zebrafish retina.PLoS computational biology · 2012Article
- PALS1 is essential for retinal pigment epithelium structure and neural retina stratification.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Essential genes for astroglial development and axon pathfinding during zebrafish embryogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Restricted localization of ponli, a novel zebrafish MAGUK-family protein, to the inner segment interface areas between green, red, and blue cones.Investigative ophthalmology & visual science · 2010Article
- Stepwise maturation of apicobasal polarity of the neuroepithelium is essential for vertebrate neurulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Proper visual function of the vertebrate retina requires the maintenance of the integrity of the retinal outer nuclear layer (ONL), which is often affected in many blinding human retinal diseases. While the structural integrity of the ONL has long been considered to be maintained primarily through the outer limiting membrane (OLM), we have little knowledge on the development and maintenance of the OLM itself. Here, by analyzing the adhering properties of photoreceptors in zebrafish N-cad and nok mutants, we demonstrated for the first time that the nok gene is essential for the establishment and/or maintenance of the OLM. In addition, our results imply the possibility that Nok, Crumbs, and their associated proteins may constitute a type of photoreceptor-photoreceptor junctional complex that has not be described before. Thus, our study provides novel insights into the mechanisms by which the integrity of the ONL is maintained in the vertebrate retina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.