ArticleBritish journal of pharmacology1991
Receptors mediating tachykinin-induced contractile responses in guinea-pig trachea.
Article in British journal of pharmacology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 70 citations in OpenAlex.
- Potency, efficacy, and selectivity of GR64349 at human recombinant neurokinin NK2 and NK1 receptors.Neuroscience letters · 2019Article
- Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK(2) receptors.British journal of pharmacology · 2000Article
- Activation of the micturition reflex by NK2 receptor stimulation in the anaesthetized guinea-pig.British journal of pharmacology · 1995Article
- Structural comparison of NK2 receptor agonists and antagonists.Journal of computer-aided molecular design · 1994Article
- Differences in the effects of NK1-receptor antagonists, (+/-)-CP 96,345 and CP 99,994, on agonist-induced responses in guinea-pig trachea.British journal of pharmacology · 1994Article
- Characterization of the tachykinin NK2 receptor in the human bronchus: influence of amastatin-sensitive metabolic pathways.British journal of pharmacology · 1994Article
- Depression of primary afferent-evoked responses by GR71251 in the isolated spinal cord of the neonatal rat.British journal of pharmacology · 1993Article
- Identification of both NK1 and NK2 receptors in guinea-pig airways.British journal of pharmacology · 1993Article
- Effects of two novel tachykinin antagonists, FK224 and FK888, on neurogenic airway plasma exudation, bronchoconstriction and systemic hypotension in guinea-pigs in vivo.British journal of pharmacology · 1993Article
- Neurokinin-induced changes in pial artery diameter in the anaesthetized guinea-pig.British journal of pharmacology · 1993Article
- Neurokinin A-induced contraction of guinea-pig isolated trachea: potentiation by hepoxilins.British journal of pharmacology · 1992Article
- Tachykinin receptors in rabbit airways--characterization by functional, autoradiographic and binding studies.British journal of pharmacology · 1992Article
- Bronchodilatation by tachykinins and capsaicin in the mouse main bronchus.British journal of pharmacology · 1992Article
- Differences in neurokinin receptor pharmacology between rat and guinea-pig superior cervical ganglia.British journal of pharmacology · 1992Article
- Investigation into species variants in tachykinin NK1 receptors by use of the non-peptide antagonist, CP-96,345.British journal of pharmacology · 1991Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The classification of tachykinin receptors in the guinea-pig trachea has been investigated. This was of interest because, from previous studies, it was not clear whether the guinea-pig trachea contains either a mixture of NK1 and NK2 receptors or, alternatively, a single type of novel tachykinin receptor. 2. In the present study, the guinea-pig trachea was contracted by tachykinin agonists selective for NK1 receptors (substance P methylester (SPOMe) and GR73632) or NK2 receptors (GR64349) but not NK3 receptors (senktide). 3. Against SPOMe and GR73632, the NK1 antagonist, GR71251, behaved as a reversible competitive antagonist having apparent affinity (pKB 7.05 vs SPOMe) consistent with action at NK1 receptors. GR71251 (3 microM) did not antagonize responses to GR64349. 4. The NK2 antagonists L-659,877 and Ac-Leu-Asp-Gln-Trp-Phe-Gly-NH2 (R396) antagonized GR64349 although only R396 appeared to behave competitively (pKB 5.73). Neither L-659,877 (30 microM) nor R396 (30 microM) blocked responses to SPOMe. 5. For L-659,877 and R396, comparison was made between activity in guinea-pig trachea and in preparations known to contain tachykinin receptors predominantly of the NK2 type. In the rabbit trachea, both L-659,877 and R396 had effects similar to those in guinea-pig trachea. In contrast, in the rat colon muscularis mucosae, both L-659,877 and R396 appeared to behave competitively with pKB values against GR64349 of 7.83 and 6.90 respectively. 6. It is concluded that in guinea-pig trachea, contractile responses can be induced by activation of both NK1 and NK2 receptors. The present data are discussed with reference to the proposed existence of subtypes of the NK2 receptor.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.