Evidence map›Paper›PMID 16530176›Full record

ArticleCarbohydrate research2006

Preparation and structural determination of large oligosaccharides derived from acharan sulfate.

Lianli Chi, Eva M Munoz, Hyung Seok Choi, Young Wan Ha, Yeong Shik Kim, Toshihiko Toida, Robert J Linhardt

Abstract read
In one paragraph

Article in Carbohydrate research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Evolution of glycosaminoglycans: Comparative biochemical study.Communicative & integrative biology · 2011
    Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Lianli ChiDepartment of Chemistry and Chemical Biology, Chemical and Biological Engineering, and Biology, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Eva M Munoz
Hyung Seok Choi
Young Wan Ha
Yeong Shik Kim
Toshihiko Toida
Robert J Linhardt
Rensselaer Polytechnic Institute · USSeoul National University · KRChiba University · JP

Funding

Synthetic Heparan Sulfate: Probing Biosynthesis to Prepare Defined DrugsR01HL062244 · NHLBI · UNIVERSITY OF IOWA · PI DEANGELIS, PAUL L, LINHARDT, ROBERT J · 2001 to 2016
$4.1M
SEQUENCING THE POLYSACCHARIDE COMPONENT OF PROTEOGLYCANSR01GM038060 · NIGMS · UNIVERSITY OF IOWA · PI LINHARDT, ROBERT J · 1988 to 2012
$2.8M
NHLBI NIH HHS R01 HL062244NIGMS NIH HHS R01 GM038060
6 · The paper itself

Abstract

The structures of a series of large oligosaccharides derived from acharan sulfate were characterized. Acharan sulfate is an unusual glycosaminoglycan isolated from the giant African snail, Achatina fulica. Oligosaccharides from decasaccharide to hexadecasaccharide were enzymatically prepared using heparin lyase II and purified. Capillary electrophoresis and gel electrophoresis confirmed the purity of these oligosaccharides. Their structures, determined by ESI-MS and NMR, were consistent with the major repeating sequence in acharan sulfate, -->4)-alpha-d-GlcN(p)Ac-(1-->4)-alpha-l-IdoA(p)2S-(1-->, terminated by 4-linked alpha-d-GlcN(p)Ac residue at the reducing end and by 4,5-unsaturated pyranosyluronic acid 2-sulfate at the non-reducing end.

Indexed as

AnimalsBacteroidaceaeCarbohydrate SequenceCatalysisElectrophoresis, CapillaryElectrophoresis, Polyacrylamide GelGlycosaminoglycansHeparin LyaseMolecular WeightNuclear Magnetic Resonance, BiomolecularOligosaccharidesSnailsSpectrometry, Mass, Electrospray Ionizationacharan sulfateGlycosaminoglycansHeparin LyaseOligosaccharides

Identifiers

PMID16530176
PMCPMC4140629
OpenAlexW2043625951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.