ReviewBrain research2006
Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development.
Review in Brain research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 4 syntheses or guidelines pooled it, 104 citations in OpenAlex.
- Risk factors for residual dizziness in patients with benign paroxysmal positional vertigo after successful repositioning: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2022Pooled it
- Prevention of recurrent benign paroxysmal positional vertigo with vitamin D supplementation: a meta-analysis.Journal of neurology · 2022Pooled it
- A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo.Communications biology · 2021Pooled it
- Clinical significance of cervical and ocular vestibular evoked myogenic potentials in benign paroxysmal positional vertigo: a meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2019Pooled it
- Characterization of inner ear granular bodies by polarization-resolved second harmonic generation microscopy.Biomedical optics express · 2026Article
- Investigation of Serum Calcium and Vitamin D Levels in Patients with Refractory Benign Paroxysmal Positional Vertigo.Turkish archives of otorhinolaryngology · 2025Article
- Vitamin D supplementation in preventing the recurrence of benign paroxysmal positional vertigo.Laryngoscope investigative otolaryngology · 2024Article
- Effects of aging on otolith morphology and functions in mice.Frontiers in neuroscience · 2024Article
- Otoconial Degeneration After Transient Ischemia Induced by Four-Vessel Occlusion in Rats.Journal of clinical neurology (Seoul, Korea) · 2023Article
- Three-dimensionally visualized ossification and mineralization process of the otic capsule in a postnatal developmental mouse.Laryngoscope investigative otolaryngology · 2023Article
- Second harmonic generation microscopy of otoconia.Biomedical optics express · 2022Article
- Advances in otolith-related protein research.Frontiers in neuroscience · 2022Review
- Otoconia Structure After Short- and Long-Duration Exposure to Altered Gravity.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- CACHD1-deficient mice exhibit hearing and balance deficits associated with a disruption of calcium homeostasis in the inner ear.Hearing research · 2021Article
- Development of a new method for assessing otolith function in mice using three-dimensional binocular analysis of the otolith-ocular reflex.Scientific reports · 2021Article
- Relation between vitamin D deficiency and benign paroxysmal positional vertigo.Scientific reports · 2021Article
- Association between benign paroxysmal positional vertigo and osteoporosis: two nested case-control studies.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- A mouse model for benign paroxysmal positional vertigo with genetic predisposition for displaced otoconia.Genes, brain, and behavior · 2020Article
- Antagonistic Inhibitory Circuits Integrate Visual and Gravitactic Behaviors.Current biology : CB · 2020Article
- Benign Paroxysmal Positional Vertigo Risk Factors Unique to Perimenopausal Women.Frontiers in neurology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Human vestibular dysfunction is an increasing clinical problem. Degeneration or displacement of otoconia is a significant etiology of age-related balance disorders and Benign Positional Vertigo (BPV). In addition, commonly used antibiotics, such as aminoglycoside antibiotics, can lead to disruption of otoconial structure and function. Despite such clinical significance, relatively little information has been compiled about the development and maintenance of otoconia in humans. Recent studies in model organisms and other mammalian organ systems have revealed some of the proteins and processes required for the normal biomineralization of otoconia and otoliths in the inner ear of vertebrates. Orchestration of extracellular biomineralization requires bringing together ionic and proteinaceous components in time and space. Coordination of these events requires the normal formation of the otocyst and sensory maculae, specific secretion and localization of extracellular matrix proteins, as well as tight regulation of the endolymph ionic environment. Disruption of any of these processes can lead to the formation of abnormally shaped, or ectopic, otoconia, or otoconial agenesis. We propose that normal generation of otoconia requires a complex temporal and spatial control of developmental and biochemical events. In this review, we suggest a new hypothetical model for normal otoconial and otolith formation based on matrix vesicle mineralization in bone which we believe to be supported by information from existing mutants, morphants, and biochemical studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.