ArticleThe Journal of general virology2006
Core protein cleavage by signal peptide peptidase is required for hepatitis C virus-like particle assembly.
Article in The Journal of general virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Life after Cleavage: The Story of a β-Retroviral (MMTV) Signal Peptide-From Murine Lymphoma to Human Breast Cancer.Viruses · 2022Review
- Review
- Physiological functions of SPP/SPPL intramembrane proteases.Cellular and molecular life sciences : CMLS · 2020Review
- Hepatitis C virus: Morphogenesis, infection and therapy.World journal of hepatology · 2018Review
- Plant-derived antivirals against hepatitis c virus infection.Virology journal · 2018Review
- Hepatitis C Virus Is Released via a Noncanonical Secretory Route.Journal of virology · 2016Article
- A new immunization and treatment strategy for mouse mammary tumor virus (MMTV) associated cancers.Oncotarget · 2016Article
- The Replacement of 10 Non-Conserved Residues in the Core Protein of JFH-1 Hepatitis C Virus Improves Its Assembly and Secretion.PloS one · 2015Article
- Bidirectional lipid droplet velocities are controlled by differential binding strengths of HCV core DII protein.PloS one · 2013Article
- Structural analysis of hepatitis C virus core-E1 signal peptide and requirements for cleavage of the genotype 3a signal sequence by signal peptide peptidase.Journal of virology · 2012Article
- High-throughput screening and rapid inhibitor triage using an infectious chimeric Hepatitis C virus.PloS one · 2012Article
- Ultrastructural and quantitative analysis of the lipid droplet clustering induced by hepatitis C virus core protein.Cellular and molecular life sciences : CMLS · 2010Article
- Identification of cellular genes affecting the infectivity of foot-and-mouth disease virus.Journal of virology · 2009Article
- Signal peptide peptidases: a family of intramembrane-cleaving proteases that cleave type 2 transmembrane proteins.Seminars in cell & developmental biology · 2009Review
- Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation.Journal of virology · 2008Article
- Hepatitis C virus budding at lipid droplet-associated ER membrane visualized by 3D electron microscopy.Histochemistry and cell biology · 2008Article
- Viral detection by electron microscopy: past, present and future.Biology of the cell · 2008Article
- Hepatitis C virus core protein binding to lipid membranes: the role of domains 1 and 2.Journal of viral hepatitis · 2008Article
- Alanine scanning of the hepatitis C virus core protein reveals numerous residues essential for production of infectious virus.Journal of virology · 2007Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis C virus (HCV) core protein, expressed with a Semliki Forest virus replicon, self-assembles into HCV-like particles (HCV-LP) at the endoplasmic reticulum (ER) membrane, providing an opportunity to study HCV assembly and morphogenesis by electron microscopy. This model was used to investigate whether the processing of the HCV core protein by the signal peptide peptidase (SPP) is required for the HCV-LP assembly. Several mutants were designed as there are conflicting reports concerning the cleavage of mutant proteins by SPP. Production of the only core mutant protein that escaped SPP processing led to the formation of multiple layers of electron-dense ER membrane, with no evidence of HCV-LP assembly. These data shed light on the HCV core residues involved in SPP cleavage and suggest that this cleavage is essential for HCV assembly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.