ArticleBlood2006
Patterns of autoimmunity and subsequent chronic lymphocytic leukemia in Nordic countries.
Article in Blood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Risk of Hematologic Malignancies in Elderly Patients With Ankylosing Spondylitis: A Cohort Study and Systematic Review.Mayo Clinic proceedings · 2023Pooled it
- Meta-analysis of genome-wide association studies reveals genetic overlap between Hodgkin lymphoma and multiple sclerosis.International journal of epidemiology · 2016Pooled it
- Chronic lymphocytic leukemia and autoimmunity: a systematic review.Haematologica · 2011Pooled it
- Rheumatic Heart Disease in Europe: Insights from a Pilot Screening Study and a Scoping Review.Global heart · 2026Article
- Complete Immunophenotypic Reversal of Chronic Lymphocytic Leukaemia With High Dose Parenteral Methylcobalamin: A Case Report and Brief Review of Cobalamin in Cancer.Cancer reports (Hoboken, N.J.) · 2025Review
- Antinuclear Antibodies Are Associated with an Increased Risk of Diffuse Large B-Cell Lymphoma.Cancers · 2023Article
- Antibodies Produced by CLL Phenotype B Cells in Patients With Myasthenia Gravis Are Not Directed Against Neuromuscular Endplates.Neurology(R) neuroimmunology & neuroinflammation · 2023Article
- Familial Risks between Pernicious Anemia and Other Autoimmune Diseases in the Population of Sweden.Autoimmune diseases · 2021Article
- Genomic imprinting analyses identify maternal effects as a cause of phenotypic variability in type 1 diabetes and rheumatoid arthritis.Scientific reports · 2020Article
- Autoimmune Complications in Chronic Lymphocytic Leukemia in the Era of Targeted Drugs.Cancers · 2020Review
- Article
- Subacute herpes simplex virus type 1 encephalitis as an initial presentation of chronic lymphocytic leukemia and multiple sclerosis: a case report.Journal of medical case reports · 2011Article
- Torque teno virus 10 isolated by genome amplification techniques from a patient with concomitant chronic lymphocytic leukemia and polycythemia vera.Molecular medicine (Cambridge, Mass.) · 2011Article
- Survival patterns in patients with Hodgkin's lymphoma with a pre-existing hospital discharge diagnosis of autoimmune disease.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2010Article
- Autoimmune complications in chronic lymphocytic leukaemia (CLL).Best practice & research. Clinical haematology · 2010Review
- Genetic and immune-related factors in the pathogenesis of lymphoproliferative and plasma cell malignancies.Haematologica · 2009Review
- Autoimmunity and lymphomagenesis.International journal of cancer · 2009Review
- B-cell clones as early markers for chronic lymphocytic leukemia.The New England journal of medicine · 2009Article
- Increased risk for non-Hodgkin lymphoma in individuals with celiac disease and a potential familial association.Gastroenterology · 2009Article
- Shared susceptibility for celiac disease and inflammatory bowel disease?Scandinavian journal of gastroenterology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
A population-based case-control study was conducted to evaluate risk of developing chronic lymphocytic leukemia (CLL) associated with personal and/or family history of autoimmune and related diseases. Data were obtained for all (n = 7764) patients diagnosed with CLL in Sweden and Denmark over a 40-year period and with linkable relatives, 16,658 matched control subjects, and first-degree relatives of patients (n = 17,991) and control subjects (n = 39,388). Odds ratios (ORs) were calculated to quantify risk of CLL in relation to personal/family history of 32 autoimmune and related disorders. The risk of CLL was significantly increased among subjects with a personal history of pernicious anemia (OR = 1.94; 1.18-3.18), mainly in the 0- to 1-year latency period. A significantly decreased risk of CLL was found among individuals with a personal history of chronic rheumatic heart disease (OR = 0.55; 0.33-0.93), particularly persons with a long latency (10+ years) between the 2 conditions. We found no association between personal or familial occurrence of other autoimmune or related disorders and CLL. If our results are confirmed, mechanistic studies examining how pernicious anemia might promote increased occurrence of CLL and how chronic rheumatic heart disease protects against CLL, perhaps related to long-term antibiotics use, may provide insights to the as-yet-unknown etiology of CLL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.