ArticleProceedings of the National Academy of Sciences of the United States of America1991
The c-mos gene product is required for cyclin B accumulation during meiosis of mouse eggs.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- MOS is a key regulator of meiotic midbody assembly and prevents abnormal divisions in mouse eggs and their polar bodies.Journal of cell science · 2026Article
- Method to isolate polyribosomal mRNA from scarce samples such as mammalian oocytes and early embryos.BMC developmental biology · 2011Article
- Mos in the oocyte: how to use MAPK independently of growth factors and transcription to control meiotic divisions.Journal of signal transduction · 2011Article
- Mos is not required for the initiation of meiotic maturation in Xenopus oocytes.The EMBO journal · 2002Article
- Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes.Genes & development · 2000Article
- In vivo antisense oligodeoxynucleotide mapping reveals masked regulatory elements in an mRNA dormant in mouse oocytes.Molecular and cellular biology · 1997Article
- Spontaneous and sperm-induced activation of oocytes in LT/Sv strain mice.Development, growth & differentiation · 1995Article
- Identification of a candidate c-mos repressor that restricts transcription of germ cell-specific genes.Molecular and cellular biology · 1995Article
- Translational control by cytoplasmic polyadenylation of c-mos mRNA is necessary for oocyte maturation in the mouse.The EMBO journal · 1994Article
- Microtubule dependency of p34cdc2 inactivation and mitotic exit in mammalian cells.The Journal of cell biology · 1994Article
- The metaphase II arrest in mouse oocytes is controlled through microtubule-dependent destruction of cyclin B in the presence of CSF.The EMBO journal · 1993Article
- Requirement of mosXe protein kinase for meiotic maturation of Xenopus oocytes induced by a cdc2 mutant lacking regulatory phosphorylation sites.Molecular and cellular biology · 1992Article
- Differential occurrence of CSF-like activity and transforming activity of Mos during the cell cycle in fibroblasts.The EMBO journal · 1992Article
- Identification of a negative regulatory element that inhibits c-mos transcription in somatic cells.Molecular and cellular biology · 1992Article
- c-mos expression in mouse oocytes is controlled by initiator-related sequences immediately downstream of the transcription initiation site.Molecular and cellular biology · 1991Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The c-mos protooncogene is expressed as a maternal message that is required for oocyte meiosis. The mechanism of action of c-mos was investigated by analysis of mouse eggs injected with antisense c-mos oligonucleotides. In antisense-injected eggs, maturation-promoting factor was not reactivated after the completion of meiosis I, leading to the formation of nuclei containing decondensed chromatin within 2-3 hr after polar body extrusion. This was correlated with a failure of the injected eggs to accumulate newly synthesized cyclin B. The c-mos protooncogene thus appears to affect the pathway that regulates cyclin B stability during meiosis of mouse eggs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.