ArticleProceedings of the National Academy of Sciences of the United States of America1991
Human immunodeficiency virus induction of malignant transformation in human B lymphocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 91 citations in OpenAlex.
- Pediatric AIDS-associated lymphocytic interstitial pneumonia and pulmonary arterio-occlusive disease: role of VCAM-1/VLA-4 adhesion pathway and human herpesviruses.The American journal of pathology · 1999Trial
- Lymphoma Imaging in HIV and Non-HIV Patients: A Retrospective Cross-Sectional Study With Clinical and Pathological Correlation.Cancer informatics · 2025Article
- Visualizing and Analyzing Global Trends and Frontier Research in HIV Reservoirs: A Bibliometric Study from 1994 to 2023.Current HIV research · 2025Article
- Carcinogenic mechanisms of virus-associated lymphoma.Frontiers in immunology · 2024Review
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- EBV renders B cells susceptible to HIV-1 in humanized mice.Life science alliance · 2020Article
- Computational design optimization for microfluidic magnetophoresis.Biomicrofluidics · 2011Article
- EBV and HIV-Related Lymphoma.Mediterranean journal of hematology and infectious diseases · 2009Article
- HIV infection and lymphoma.Journal of clinical pathology · 2007Review
- HIV-1 Vpr induces ATM-dependent cellular signal with enhanced homologous recombination.Oncogene · 2007Article
- Virus-associated lymphomagenesis.International journal of biomedical science : IJBS · 2006Article
- Molecular and immunophenotypical characterization of a feline immunodeficiency virus (FIV)-associated lymphoma: a direct role for FIV in B-lymphocyte transformation?Journal of virology · 1998Article
- Recovery from retrovirus-induced immune suppression in BDP/J mice: dominance of the "regressor' phenotype.Immunology · 1997Article
- Inhibition of clinical human immunodeficiency virus (HIV) type 1 isolates in primary CD4+ T lymphocytes by retroviral vectors expressing anti-HIV genes.Journal of virology · 1995Article
- The antimitotic drug 4,6-dimethyl-2-amino-3,4,5- trimethoxyphenyl-pyrimidine inhibits the nucleoside transport system of cells from various animal species.Experientia · 1994Article
- Epitopes for natural antibodies of human immunodeficiency virus (HIV)-negative (normal) and HIV-positive sera are coincident with two key functional sequences of HIV Tat protein.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Epstein-Barr virus infection in HIV-positive patients.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1993Article
- Epstein-Barr virus latent membrane protein transactivates the human immunodeficiency virus type 1 long terminal repeat through induction of NF-kappa B activity.Journal of virology · 1992Article
- Human immunodeficiency virus (HIV) Tat-reactive antibodies present in normal HIV-negative sera and depleted in HIV-positive sera. Identification of the epitope.The Journal of experimental medicine · 1992Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Aggressive B-cell lymphomas are occurring with increasing incidence among individuals infected with human immunodeficiency virus (HIV). Several lines of evidence implicate both Epstein-Barr virus (EBV) and c-myc activation in the pathogenesis of a major subset of these tumors. These observations prompted our investigation of interactions among EBV, c-myc, and HIV in primary B cells. We show that nonimmortalized peripheral B lymphocytes from EBV-seropositive, HIV-seronegative donors can be infected by HIV and that a subset of these lymphocytes become transformed. Malignant transformation was documented by several criteria. These cells displayed altered growth properties, propagating in 1% serum and cloning in soft agar, and formed invasive tumors of Burkitt lymphoma phenotype after subcutaneous injection into severe combined immunodeficiency mice. Such cells revealed marked enhancement of EBV DNA and RNA and of endogenous c-myc transcripts and protein. HIV-1 infection of already immortalized B-cell lines led to a similar upregulation of EBV and c-myc transcripts. These data indicate that HIV has properties of a transforming retrovirus, as it mediates two events linked to B-cell neoplasia: deregulation of c-myc and activation of EBV. They also raise the possibility of a role for HIV, apart from induction of immune suppression, in the pathogenesis of B-cell lymphoma in the acquired immune deficiency syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.