ArticleBMC genetics2006
QTL for microstructural and biophysical muscle properties and body composition in pigs.
Article in BMC genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 91 citations in OpenAlex.
- Integrative genetic and epigenetic control of skeletal muscle fiber traits in agricultural animals.Frontiers in genetics · 2025Review
- Expression mechanisms of mir-486-5p and its host gene sANK1 in porcine muscle.Molecular biology reports · 2024Article
- GWAS and genetic and phenotypic correlations of plasma metabolites with complete blood count traits in healthy young pigs reveal implications for pig immune response.Frontiers in molecular biosciences · 2023Article
- Integration of multi-omics data reveals cis-regulatory variants that are associated with phenotypic differentiation of eastern from western pigs.Genetics, selection, evolution : GSE · 2022Article
- A whole genome sequence association study of muscle fiber traits in a White Duroc×Erhualian F2 resource population.Asian-Australasian journal of animal sciences · 2020Article
- Screening for candidate genes related with histological microstructure, meat quality and carcass characteristic in pig based on RNA-seq data.Asian-Australasian journal of animal sciences · 2018Article
- Fine-mapping of genes determining extrafusal fiber properties in murine soleus muscle.Physiological genomics · 2017Article
- Characterization and management of long runs of homozygosity in parental nucleus lines and their associated crossbred progeny.Genetics, selection, evolution : GSE · 2016Article
- Copy number variation-based genome wide association study reveals additional variants contributing to meat quality in Swine.Scientific reports · 2015Article
- A genetical genomics approach reveals new candidates and confirms known candidate genes for drip loss in a porcine resource population.Mammalian genome : official journal of the International Mammalian Genome Society · 2013Article
- Genome-wide association study of meat quality traits in a White Duroc×Erhualian F2 intercross and Chinese Sutai pigs.PloS one · 2013Article
- Association and expression quantitative trait loci (eQTL) analysis of porcine AMBP, GC and PPP1R3B genes with meat quality traits.Molecular biology reports · 2012Article
- Association between promoter polymorphisms in a key cytoskeletal gene (Ankyrin 1) and intramuscular fat and water-holding capacity in porcine muscle.Molecular biology reports · 2012Article
- Imprinting analysis of porcine DIO3 gene in two fetal stages and association analysis with carcass and meat quality traits.Molecular biology reports · 2012Article
- Genes with expression levels correlating to drip loss prove association of their polymorphism with water holding capacity of pork.Molecular biology reports · 2012Article
- QTL Analysis of Type I and Type IIA Fibers in Soleus Muscle in a Cross between LG/J and SM/J Mouse Strains.Frontiers in genetics · 2011Article
- MyoD control of SKIP expression during pig skeletal muscle development.Molecular biology reports · 2011Article
- Identification of Carcass and Meat Quality QTL in an F(2) Duroc × Pietrain Pig Resource Population Using Different Least-Squares Analysis Models.Frontiers in genetics · 2011Article
- Four loci differentially expressed in muscle tissue depending on water-holding capacity are associated with meat quality in commercial pig herds.Molecular biology reports · 2010Article
- Dual effect of a single nucleotide polymorphism in the first intron of the porcine secreted phosphoprotein 1 gene: allele-specific binding of C/EBP beta and activation of aberrant splicing.BMC molecular biology · 2009Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe proportion of muscle fibre types and their size affect muscularity as well as functional properties of the musculature and meat quality. We aimed to identify QTL for microstructural muscle properties including muscle fibre size, their numbers and fibre type proportions as well as biophysical parameters of meat quality and traits related to body composition, i.e. pH, conductivity, area of M. longissimus dorsi and lean meat content. A QTL scan was conducted in a porcine experimental population that is based on Duroc and Berlin Miniature Pig.
resultsLeast square regression interval mapping revealed five significant and 42 suggestive QTL for traits related to muscle fibre composition under the line-cross model as well as eight significant and 40 suggestive QTL under the half-sib model. For traits related to body composition and biophysical parameters of meat quality five and twelve significant plus nine and 22 suggestive QTL were found under the line-cross and half-sib model, respectively. Regions with either significant QTL for muscle fibre traits or significant QTL for meat quality and muscularity or both were detected on SSC1, 2, 3, 4, 5, 13, 14, 15, and 16. QTL for microstructural properties explained a larger proportion of variance than did QTL for meat quality and body composition.
conclusionMicrostructural properties of pig muscle and meat quality are governed by genetic variation at many loci distributed throughout the genome. QTL analysis under both, the line-cross and half-sib model, allows detecting QTL in case of fixation or segregation of the QTL alleles among the founder populations and thus provide comprehensive insight into the genetic variation of the traits under investigation. Genomic regions affecting complex traits of muscularity and meat quality as well as microstructural properties might point to QTL that in first instance affect muscle fibre traits and by this in second instance meat quality. Disentangling complex traits in their constituent phenotypes might facilitate the identification of QTL and the elucidation of the pleiotropic nature of QTL effects.
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Registered trials
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