ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
D-aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase-deficient mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 72 citations in OpenAlex.
- Impacts of conditionally essential amino acids, cysteine, and tyrosine on intestinal inflammation in celiac disease.Amino acids · 2025Review
- Mammalian Tolerance to Amino Acid Heterochirality.Chembiochem : a European journal of chemical biology · 2025Review
- Regulation of d-Aspartate Oxidase Gene Expression by Pyruvate Metabolism in the YeastMicroorganisms · 2021Article
- D-cysteine is an endogenous regulator of neural progenitor cell dynamics in the mammalian brain.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Identification of an Acidic Amino Acid Permease Involved in d-Aspartate Uptake in the YeastMicroorganisms · 2021Article
- New Evidence on the Role of D-Aspartate Metabolism in Regulating Brain and Endocrine System Physiology: From Preclinical Observations to Clinical Applications.International journal of molecular sciences · 2020Review
- Race-specific alterations in DNA methylation among middle-aged African Americans and Whites with metabolic syndrome.Epigenetics · 2020Article
- D-Aspartic Acid in Vertebrate Reproduction: Animal Models and Experimental DesignsBiomolecules · 2019Review
- The Emerging Role of Altered d-Aspartate Metabolism in Schizophrenia: New Insights From Preclinical Models and Human Studies.Frontiers in psychiatry · 2018Review
- Therapeutic effects of D-aspartate in a mouse model of multiple sclerosis.Journal of food and drug analysis · 2017Article
- Epigenetic modifications and glucocorticoid sensitivity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).BMC medical genomics · 2017Article
- The putative effects of D-Aspartic acid on blood testosterone levels: A systematic review.International journal of reproductive biomedicine · 2017Review
- Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- D-Amino Acids in the Nervous and Endocrine Systems.Scientifica · 2016Review
- A role for D-aspartate oxidase in schizophrenia and in schizophrenia-related symptoms induced by phencyclidine in mice.Translational psychiatry · 2015Article
- Review
- Crystallization and preliminary crystallographic analysis of D-aspartate oxidase from porcine kidney.Acta crystallographica. Section F, Structural biology and crystallization communications · 2012Article
- D-aspartate prevents corticostriatal long-term depression and attenuates schizophrenia-like symptoms induced by amphetamine and MK-801.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- From the Cover: Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Signal Cloaking by Electric Fish.BioscienceArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
D-aspartate, an abundant D-amino acid enriched in neuroendocrine tissues, can be degraded by D-aspartate oxidase (Ddo). To elucidate the function of D-aspartate, we generated mice with targeted deletion of Ddo (Ddo(-/-)) and observe massive but selective augmentations of D-aspartate in various tissues. The pituitary intermediate lobe, normally devoid of D-aspartate from endogenous Ddo expression, manifests pronounced increases of immunoreactive D-aspartate in Ddo(-/-) mice. Ddo(-/-) mice show markedly diminished synthesis and levels of pituitary proopiomelanocortin/alpha-MSH, associated with decreased melanocortin-dependent behaviors. Therefore, Ddo is the endogenous enzyme that degrades D-aspartate, and Ddo-enriched organs, low in D-aspartate, may represent areas of high turnover where D-aspartate may be physiologically important.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.