ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Depolarization of cochlear outer hair cells evokes active hair bundle motion by two mechanisms.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed, 90 citations in OpenAlex.
- 3D morphology of an outer-hair-cell hair bundle increases its displacement and dynamic range.Biophysical journal · 2024Article
- Characterisation of the static offset in the travelling wave in the cochlear basal turn.Pflugers Archiv : European journal of physiology · 2020Article
- Auditory Neural Plasticity in Tinnitus Mechanisms and Management.Neural plasticity · 2020Review
- Stiffness and tension gradients of the hair cell's tip-link complex in the mammalian cochlea.eLife · 2019Article
- Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea.Comprehensive Physiology · 2017Review
- Energy Flux in the Cochlea: Evidence Against Power Amplification of the Traveling Wave.Journal of the Association for Research in Otolaryngology : JARO · 2015Article
- Effects of salicylate on sound-evoked outer hair cell stereocilia deflections.Pflugers Archiv : European journal of physiology · 2015Article
- Article
- The physiology of mechanoelectrical transduction channels in hearing.Physiological reviews · 2014Review
- A clinically oriented introduction and review on finite element models of the human cochlea.BioMed research international · 2014Article
- Effects of cochlear loading on the motility of active outer hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Mechanical overstimulation of hair bundles: suppression and recovery of active motility.PloS one · 2013Article
- Contribution of active hair-bundle motility to nonlinear amplification in the mammalian cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- How are inner hair cells stimulated? Evidence for multiple mechanical drives.Hearing research · 2012Article
- Coupling and elastic loading affect the active response by the inner ear hair cell bundles.PloS one · 2012Article
- Sound-induced length changes in outer hair cell stereocilia.Nature communications · 2012Article
- Biophysical mechanisms underlying outer hair cell loss associated with a shortened tectorial membrane.Journal of the Association for Research in Otolaryngology : JARO · 2011Article
- Prestin-driven cochlear amplification is not limited by the outer hair cell membrane time constant.Neuron · 2011Article
- The endocochlear potential alters cochlear micromechanics.Biophysical journal · 2011Article
- Somatic motility and hair bundle mechanics, are both necessary for cochlear amplification?Hearing research · 2011Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
There is current debate about the origin of mechanical amplification whereby outer hair cells generate force to augment the sensitivity and frequency selectivity of the mammalian cochlea. To distinguish contributions to force production from the mechanotransducer (MET) channels and somatic motility, we have measured hair bundle motion during depolarization of individual outer hair cells in isolated rat cochleas. Depolarization evoked rapid positive bundle deflections that were reduced by perfusion with the MET channel blocker dihydrostreptomycin, with no effect on the nonlinear capacitance that is a manifestation of prestin-driven somatic motility. However, the movements were also diminished by Na salicylate and depended on the intracellular anion, properties implying involvement of the prestin motor. Furthermore, depolarization of one outer hair cell caused motion of neighboring hair bundles, indicating overall motion of the reticular lamina. Depolarization of solitary outer hair cells caused cell-length changes whose voltage-activation range depended on the intracellular anion but were insensitive to dihydrostreptomycin. These results imply that both the MET channels and the somatic motor participate in hair bundle motion evoked by depolarization. It is conceivable that the two processes can interact, a signal from the MET channels being capable of modulating the activity of the prestin motor.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.