ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Robustness of neural coding in Drosophila photoreceptors in the absence of slow delayed rectifier K+ channels.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 68 citations in OpenAlex.
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- Distinct expression of potassium channels regulates visual response properties of lamina neurons in Drosophila melanogaster.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2020Article
- CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Modulation of voltage-dependent K+ conductances in photoreceptors trades off investment in contrast gain for bandwidth.PLoS computational biology · 2018Article
- Transcriptome profiling of aging Drosophila photoreceptors reveals gene expression trends that correlate with visual senescence.BMC genomics · 2017Article
- Article
- A biomimetic fly photoreceptor model elucidates how stochastic adaptive quantal sampling provides a large dynamic range.The Journal of physiology · 2017Review
- EAG channels expressed in microvillar photoreceptors are unsuited to diurnal vision.The Journal of physiology · 2017Article
- How a fly photoreceptor samples light information in time.The Journal of physiology · 2017Review
- Insect photoreceptor adaptations to night vision.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Genetic perturbations suggest a role of the resting potential in regulating the expression of the ion channels of the KCNA and HCN families in octopus cells of the ventral cochlear nucleus.Hearing research · 2017Article
- Electrophysiological Method for Recording Intracellular Voltage Responses of Drosophila Photoreceptors and Interneurons to Light Stimuli In Vivo.Journal of visualized experiments : JoVE · 2016Article
- Visual ecology and potassium conductances of insect photoreceptors.Journal of neurophysiology · 2016Article
- Evidence for Dynamic Network Regulation of Drosophila Photoreceptor Function from Mutants Lacking the Neurotransmitter Histamine.Frontiers in neural circuits · 2016Article
- EAG2 potassium channel with evolutionarily conserved function as a brain tumor target.Nature neuroscience · 2015Article
- Transcriptome analysis and RNA interference of cockroach phototransduction indicate three opsins and suggest a major role for TRPL channels.Frontiers in physiology · 2015Article
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- Identifying crucial parameter correlations maintaining bursting activity.PLoS computational biology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Determining the contribution of a single type of ion channel to information processing within a neuron requires not only knowledge of the properties of the channel but also understanding of its function within a complex system. We studied the contribution of slow delayed rectifier K+ channels to neural coding in Drosophila photoreceptors by combining genetic and electrophysiological approaches with biophysical modeling. We show that the Shab gene encodes the slow delayed rectifier K+ channel and identify a novel voltage-gated K+ conductance. Analysis of the in vivo recorded voltage responses together with their computer-simulated counterparts demonstrates that Shab channels in Drosophila photoreceptors attenuate the light-induced depolarization and prevent response saturation in bright light. We also show that reduction of the Shab conductance in mutant photoreceptors is accompanied by a proportional drop in their input resistance. This reduction in input resistance partially restores the signaling range, sensitivity, and dynamic coding of light intensities of Shab photoreceptors to those of the wild-type counterparts. However, loss of the Shab channels may affect both the energy efficiency of coding and the processing of natural stimuli. Our results highlight the role of different types of voltage-gated K+ channels in the performance of the photoreceptors and provide insight into functional robustness against the perturbation of specific ion channel composition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.