ArticleEukaryotic cell2006
Fe-hydrogenase maturases in the hydrogenosomes of Trichomonas vaginalis.
Article in Eukaryotic cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Taxonomic distribution and evolutionary analysis of the equol biosynthesis gene cluster.BMC genomics · 2022Article
- Molecular Hydrogen Metabolism: a Widespread Trait of Pathogenic Bacteria and Protists.Microbiology and molecular biology reviews : MMBR · 2020Review
- Revealing the metabolic capacity ofProceedings of the National Academy of Sciences of the United States of America · 2019Article
- A nonmitochondrial hydrogen production in Naegleria gruberi.Genome biology and evolution · 2014Article
- Article
- Evidence for a hydrogenosomal-type anaerobic ATP generation pathway in Acanthamoeba castellanii.PloS one · 2013Article
- Hydrogenosomes in the diplomonad Spironucleus salmonicida.Nature communications · 2013Article
- The mitochondrion-like organelle of Trimastix pyriformis contains the complete glycine cleavage system.PloS one · 2013Article
- Biochemistry and evolution of anaerobic energy metabolism in eukaryotes.Microbiology and molecular biology reviews : MMBR · 2012Review
- Structure-function relationships in [FeFe]-hydrogenase active site maturation.The Journal of biological chemistry · 2012Review
- A machine learning approach to identify hydrogenosomal proteins in Trichomonas vaginalis.Eukaryotic cell · 2012Article
- Transcriptomic identification of iron-regulated and iron-independent gene copies within the heavily duplicated Trichomonas vaginalis genome.Genome biology and evolution · 2012Article
- The Trichomonas vaginalis hydrogenosome proteome is highly reduced relative to mitochondria, yet complex compared with mitosomes.International journal for parasitology · 2011Article
- Sawyeria marylandensis (Heterolobosea) has a hydrogenosome with novel metabolic properties.Eukaryotic cell · 2010Article
- Diversity and reductive evolution of mitochondria among microbial eukaryotes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Shewanella oneidensis: a new and efficient system for expression and maturation of heterologous [Fe-Fe] hydrogenase from Chlamydomonas reinhardtii.BMC biotechnology · 2008Article
- Genetic evidence for a mitochondriate ancestry in the 'amitochondriate' flagellate Trimastix pyriformis.PloS one · 2008Article
- Hydrogen production by termite gut protists: characterization of iron hydrogenases of Parabasalian symbionts of the termite Coptotermes formosanus.Eukaryotic cell · 2007Article
- Current therapeutics, their problems, and sulfur-containing-amino-acid metabolism as a novel target against infections by "amitochondriate" protozoan parasites.Clinical microbiology reviews · 2007Review
- Proteins of the glycine decarboxylase complex in the hydrogenosome of Trichomonas vaginalis.Eukaryotic cell · 2006Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Assembly of active Fe-hydrogenase in the chloroplasts of the green alga Chlamydomonas reinhardtii requires auxiliary maturases, the S-adenosylmethionine-dependent enzymes HydG and HydE and the GTPase HydF. Genes encoding homologous maturases had been found in the genomes of all eubacteria that contain Fe-hydrogenase genes but not yet in any other eukaryote. By means of proteomic analysis, we identified a homologue of HydG in the hydrogenosomes, mitochondrion-related organelles that produce hydrogen under anaerobiosis by the activity of Fe-hydrogenase, in the pathogenic protist Trichomonas vaginalis. Genes encoding two other components of the Hyd system, HydE and HydF, were found in the T. vaginalis genome database. Overexpression of HydG, HydE, and HydF in trichomonads showed that all three proteins are specifically targeted to the hydrogenosomes, the site of Fe-hydrogenase maturation. The results of Neighbor-Net analyses of sequence similarities are consistent with a common eubacterial ancestor of HydG, HydE, and HydF in T. vaginalis and C. reinhardtii, supporting a monophyletic origin of Fe-hydrogenase maturases in the two eukaryotes. Although Fe-hydrogenases exist in only a few eukaryotes, related Narf proteins with different cellular functions are widely distributed. Thus, we propose that the acquisition of Fe-hydrogenases, together with Hyd maturases, occurred once in eukaryotic evolution, followed by the appearance of Narf through gene duplication of the Fe-hydrogenase gene and subsequent loss of the Hyd proteins in eukaryotes in which Fe-hydrogenase function was lost.
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