Evidence map›Paper›PMID 16523327›Full record

ReviewDer Urologe. Ausg. A2006

[Recurrent urinary tract infections in women. Virulence of pathogens and host reaction].

T Oelschlaeger, R Fünfstück

Abstract readReview
PubMed Publisher
In one paragraph

Review in Der Urologe. Ausg. A, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

T OelschlaegerInstitut für Molekulare Infektionsbiologie, Universität, Röntgenring 11, 97070 Würzburg. t.oelschlaeger@mail.uni-wuerzburg.de
R Fünfstück

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interactions of host-specific and microbial factors are responsible for recurrent urinary tract infections (rUTI). The anatomical properties of the female urogenital tract favor colonization by uropathogens. Local factors such as glucose concentration of the urine, stability of the lactobacilli population, the influence of estrogens, the activity of Tamm-Horsfall protein or of defensins, and disturbance of the systemic defense mechanisms dictate the course of an infection. The most prominent uropathogen is E. coli. It expresses various virulence factors including adhesions, toxins, iron uptake systems, and a capsule. It is still unclear if there are virulence factors characteristic for E. coli strains causing rUTI. The formation of intracellular reservoirs by invasion of uroepithelial cells by E. coli could be another, as yet little noticed cause for rUTI. Therefore, in cases of rUTI the application of intracellularly active antibiotics should be considered.

Indexed as

AnimalsAntibodies, BacterialAnti-Infective Agents, UrinaryBacterial AdhesionCreatinineEpitheliumEscherichia coliEscherichia coli InfectionsFemaleHumansImmune ToleranceMiceRecurrenceRisk FactorsUreaUrinary Tract InfectionsAntibodies, BacterialAnti-Infective Agents, UrinaryCreatinineUrea

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.