ArticleNucleic acids research2006
Inhibitory effects of archetypical nucleic acid ligands on the interactions of HIV-1 nucleocapsid protein with elements of Psi-RNA.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Article
- MultipleACS medicinal chemistry letters · 2020Article
- Non-Natural Linker Configuration in 2,6-Dipeptidyl-Anthraquinones Enhances the Inhibition of TAR RNA Binding/Annealing Activities by HIV-1 NC and Tat Proteins.Bioconjugate chemistry · 2018Article
- Identification of novel 2-benzoxazolinone derivatives with specific inhibitory activity against the HIV-1 nucleocapsid protein.European journal of medicinal chemistry · 2018Article
- Interactions of Protonated Guanidine and Guanidine Derivatives with Multiply Deprotonated RNA Probed by Electrospray Ionization and Collisionally Activated Dissociation.ChemistryOpen · 2017Article
- Enhancement of the physicochemical properties of [Pt(dien)(nucleobase)]Chemical science · 2017Article
- Potential inhibition of HIV-1 encapsidation by oligoribonucleotide-dendrimer nanoparticle complexes.International journal of nanomedicine · 2017Article
- Au(iii) compounds as HIV nucleocapsid protein (NCp7)-nucleic acid antagonists.Chemical communications (Cambridge, England) · 2016Article
- A simple heated-capillary modification improves the analysis of non-covalent complexes by Z-spray electrospray ionization.Rapid communications in mass spectrometry : RCM · 2016Article
- Synthesis, Binding and Antiviral Properties of Potent Core-Extended Naphthalene Diimides Targeting the HIV-1 Long Terminal Repeat Promoter G-Quadruplexes.Journal of medicinal chemistry · 2015Article
- Advances in targeting nucleocapsid-nucleic acid interactions in HIV-1 therapy.Virus research · 2014Review
- Retrospective on the all-in-one retroviral nucleocapsid protein.Virus research · 2014Review
- The essential role of stacking adenines in a two-base-pair RNA kissing complex.Journal of the American Chemical Society · 2013Article
- HIV type 1 Gag as a target for antiviral therapy.AIDS research and human retroviruses · 2012Review
- MS analysis of nucleic acids in the post-genomic era.Analytical chemistry · 2011Article
- Novel approaches to inhibiting HIV-1 replication.Antiviral research · 2010Review
- A role for the MS analysis of nucleic acids in the post-genomics age.Journal of the American Society for Mass Spectrometry · 2010Article
- Probing anomalous structural features in polypurine tract-containing RNA-DNA hybrids with neomycin B.Biochemistry · 2009Article
- Article
- Like polarity ion/ion reactions enable the investigation of specific metal interactions in nucleic acids and their noncovalent assemblies.Journal of the American Chemical Society · 2008Article
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3 authors.
Funding
Abstract
Disrupting the interactions between human immunodeficiency virus type 1 (HIV-1) nucleocapsid (NC) protein and structural elements of the packaging signal (Psi-RNA) could constitute an ideal strategy to inhibit the functions of this region of the genome leader in the virus life cycle. We have employed electrospray ionization (ESI) Fourier transform mass spectrometry (FTMS) to assess the ability of a series of nucleic acid ligands to bind selected structures of Psi-RNA and inhibit their specific interactions with NC in vitro. We found that the majority of the ligands included in the study were able to form stable non-covalent complexes with stem-loop 2, 3 and 4 (SL2-4), consistent with their characteristic nucleic acid binding modes. However, only aminoglycosidic antibiotics were capable of dissociating preformed NC*SL3 and NC*SL4 complexes, but not NC*SL2. The apparent specificity of these inhibitory effects is closely dependent on distinctive structural features of the different NC*RNA complexes. The trends observed for the IC50 values correlate very well with those provided by the ligand binding affinities and the dissociation constants of target NC*RNA complexes. This systematic investigation of archetypical nucleic acid ligands provides a valid framework to support the design of novel ligand inhibitors for HIV-1 treatment.
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