ReviewCurrent HIV/AIDS reports2006
Cellular restriction factors affecting the early stages of HIV replication.
Review in Current HIV/AIDS reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- Ring finger protein 39 genetic variants associate with HIV-1 plasma viral loads and its replication in cell culture.Cell & bioscience · 2014Article
- Variants in ZNRD1 gene predict HIV-1/AIDS disease progression in a Han Chinese population in Taiwan.PloS one · 2013Article
- HIV-1 sexual transmission: early events of HIV-1 infection of human cervico-vaginal tissue in an optimized ex vivo model.Mucosal immunology · 2010Article
- Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization.Journal of virology · 2008Article
- Implication of TRIM alpha and TRIMCyp in interferon-induced anti-retroviral restriction activities.Retrovirology · 2008Article
- Restriction of foamy viruses by primate Trim5alpha.Journal of virology · 2008Article
- The structural biology of HIV assembly.Current opinion in structural biology · 2008Review
- Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammals.PLoS pathogens · 2007Article
- Both TRIM5alpha and TRIMCyp have only weak antiviral activity in canine D17 cells.Retrovirology · 2007Article
- Neurologic disease in captive lions (Panthera leo) with low-titer lion lentivirus infection.Journal of clinical microbiology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several innate immune mechanisms exist in mammalian cells that prevent the replication of viruses. These cellular factors influence the tropism of retroviruses in mammalian cells by inducing a dominant restriction that acts after viral entry but before integration into the host genome. The identification of several cellular factors involved with the post entry block of HIV has recently been revealed. These recent advances identified the tripartite motif protein 5alpha (Trim5alpha) and the apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3G (APOBEC3G), which work to inactivate several retroviruses including HIV-1. The mechanism of restriction by these cellular proteins is unknown. Therefore, this review highlights recent advances in understanding the function of Trim5alpha and APOBEC3G.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.