ReviewCurrent HIV/AIDS reports2006
Decimated or missing in action: CD4+ T cells as targets and effectors in the pathogenesis of primary HIV infection.
Review in Current HIV/AIDS reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy.The Journal of clinical investigation · 2021Article
- CD4+ T Cells Are Dispensable for Induction of Broad Heterologous HIV Neutralizing Antibodies in Rhesus Macaques.Frontiers in immunology · 2021Article
- Article
- MicroRNA expression profiling of intestinal mucosa tissue predicts multiple crucial regulatory molecules and signaling pathways for gut barrier dysfunction of AIDS patients.Molecular medicine reports · 2017Article
- CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells.PLoS pathogens · 2014Article
- Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques.The Journal of clinical investigation · 2011Article
- Impact of ERCC2 gene polymorphism on HIV-1 disease progression to AIDS among North Indian HIV patients.Molecular biology reports · 2011Article
- Partial efficacy of a VSV-SIV/MVA-SIV vaccine regimen against oral SIV challenge in infant macaques.Vaccine · 2011Article
- Cerebral Toxoplasmosis in a Patient with AIDS on F-18 FDG PET/CT.Nuclear medicine and molecular imaging · 2010Article
- The utilization of humanized mouse models for the study of human retroviral infections.Retrovirology · 2009Review
- Positron emission tomography in patients suffering from HIV-1 infection.European journal of nuclear medicine and molecular imaging · 2009Review
- Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo.Retrovirology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
HIV infection provides a unique challenge to the immune system. CD4+ T cells are targets of infection, whereas effective anti-HIV CD4+ T-cell responses are essential for sustained viral control. There is increasing evidence of preferential depletion of certain subsets of CD4+ T cells. Studies of tissues have demonstrated preferential depletion of CD4+ T cells from gastrointestinal lymphoid tissue (GALT). Simian immunodeficiency virus infection of macaques results in extensive depletion of CD4+ memory T cells from GALT within weeks of infection. Other macaque studies suggest this rapid, profound depletion is generalized across all lymphoid tissue. Although these models provide insight into possible pathogenic processes, these results cannot be directly extrapolated to HIV infection in humans. Although there is depletion of CD4+ T cell memory cells early in HIV infection, the mechanism of this depletion appears to be related to increased cell turnover, chronicity of antigen exposure, and ineffective production of central memory CD4+ T cells rather than only direct cell depletion.
Indexed as
Identifiers
16522253What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.