ArticleWorld journal of gastroenterology2006
Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 56 citations in OpenAlex.
- Aqueous and ethanolic extracts of Moringa oleifera leaves induce selective cytotoxicity in Raji and Jurkat cell lines by activating the P21 pathway independent of P53.Molecular biology reports · 2025Article
- Combination of Oncolytic Measles Virus and Ursolic Acid Synergistically Induces Oncolysis of Hepatocellular Carcinoma Cells.Viruses · 2023Article
- Chemical Composition and Assessment of Antimicrobial Activity of Lavender Essential Oil and Some By-Products.Plants (Basel, Switzerland) · 2021Article
- Perspectives on natural compounds in chemoprevention and treatment of cancer: an update with new promising compounds.European journal of cancer (Oxford, England : 1990) · 2021Review
- Design, Synthesis, Molecular Modelling, and Biological Evaluation of Oleanolic Acid-Arylidene Derivatives as Potential Anti-Inflammatory Agents.Drug design, development and therapy · 2021Article
- Ursolic Acid Protects Against Proliferation and Inflammatory Response in LPS-Treated Gastric Tumour Model and Cells by Inhibiting NLRP3 Inflammasome Activation.Cancer management and research · 2020Article
- Anticancer effect of ursolic acid via mitochondria-dependent pathways.Oncology letters · 2019Review
- Polymeric micelles loading with ursolic acid enhancing anti-tumor effect on hepatocellular carcinoma.Journal of Cancer · 2019Article
- Moringa oleifera Root Induces Cancer Apoptosis more Effectively than Leave Nanocomposites and Its Free CounterpartAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Acute and Subacute Oral Toxicity Evaluation ofEvidence-based complementary and alternative medicine : eCAM · 2017Article
- Ursolic Acid--A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities.Molecules (Basel, Switzerland) · 2015Review
- Research progress of ursolic acid's anti-tumor actions.Chinese journal of integrative medicine · 2014Review
- Characterization of the phytochemical constituents of Taif rose and its antioxidant and anticancer activities.BioMed research international · 2013Article
- Ursolic acid induces apoptosis by suppressing the expression of FoxM1 in MCF-7 human breast cancer cells.Medical oncology (Northwood, London, England) · 2012Article
- Terpenoids as potential chemopreventive and therapeutic agents in liver cancer.World journal of hepatology · 2011Article
- Antitumor activity and mechanisms of action of total glycosides from aerial part of Cimicifuga dahurica targeted against hepatoma.BMC cancer · 2007Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the anti-tumor activity of ursolic acid (UA) and its derivatives isolated from Aralia decaisneana on hepatocellular carcinoma both in vitro and in vivo.
methodsIn vivo cytotoxicity was first screened by 3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) assay. Morphological observation, DNA ladder, flow cytometry analysis, Western blot and real time PCR were employed to elucidate the cytotoxic mechanism of UA. Implanted mouse hepatoma H22 was used to evaluate the growth inhibitory effect of UA in vivo.
resultsUA could significantly inhibit the proliferation of HepG2 and its drug-resistance strain, R-HepG2 cells, but had no inhibitory effect on primarily cultured normal mouse hepatocytes whereas all the six derivatives of UA could not inhibit the growth of all tested cell lines. Further study on mechanism demonstrated that apoptosis and G0/G1 arrest were involved in the cytotoxicity and cleavage of poly-(ADP-ribose)-polymerase (PARP). Downregulation of cyclooxygenase-2 (COX-2) protein and upregulation of heat shock protein (HSP) 105 mRNA correlated to the apoptosis of HepG2 cells treated with UA. In addition, UA also could inhibit the growth of H22 hepatoma in vivo.
conclusionUA is a promising anti-tumor agent, but further work needs to be done to improve its solubility.
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