ReviewWorld journal of gastroenterology2006
Cardiac and vascular changes in cirrhosis: pathogenic mechanisms.
Review in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04050683 (Evaluation of Hemodynamic Parameters Following Transjugular Intrahepatic Portosystemic Shunt), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of Hemodynamic Parameters Following Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- Comparison of Carvedilol to Propranolol in Reduction of Hepatic Venous Pressure Gradient in Liver Cirrhosis: A Meta-Analysis.Journal of gastroenterology and hepatology · 2025Pooled it
- Pooled it
- Effect of Prometheus liver assist system on systemic hemodynamics in patients with cirrhosis: a randomized controlled study.World journal of gastroenterology · 2008Trial
- Study of Cardiovascular Dysfunction in Cirrhosis and Its Correlation With Severity at a Tertiary Care Hospital.Cureus · 2026Article
- Aortic stenosis in cirrhosis: Pathophysiology and management in the context of liver transplantation.World journal of transplantation · 2025Review
- Novel insights into cardiac structure, function, perfusion, and tissue characteristics in liver cirrhosis: a magnetic resonance analysis.European radiology · 2025Article
- Hepato-Renal Crosstalk in Acute and Chronic Disease: From Shared Pathways to Therapeutic Targets.Biomedicines · 2025Review
- Cellular and Molecular Mechanisms Underlying Altered Excitability of Cardiac Efferent Neurons in Cirrhotic Rats.Biomedicines · 2024Article
- Evaluation of Electrocardiogram Parameters and Heart Rate Variability During Blood Pressure Elevation by Phenylephrine in Cirrhotic Rats.Cardiovascular toxicology · 2024Article
- How non-alcoholic fatty liver disease and cirrhosis affect the heart.Hepatology international · 2023Review
- Review
- Role of Anti-Beta-1-Adrenergic Receptor Antibodies in Cardiac Dysfunction in Patients with Cirrhotic Cardiomyopathy.Journal of cardiovascular translational research · 2022Article
- Cardiovascular and hepatic disease associations by magnetic resonance imaging: A retrospective cohort study.Frontiers in cardiovascular medicine · 2022Article
- Cardiovascular and Metabolic Consequences of Liver Transplantation: A Review.Medicina (Kaunas, Lithuania) · 2019Review
- Predictive Value of Dobutamine Stress Perfusion Echocardiography in Contemporary End-Stage Liver Disease.Journal of the American Heart Association · 2017Article
- Systemic hemodynamics in advanced cirrhosis: Concerns during perioperative period of liver transplantation.World journal of hepatology · 2016Review
- Myocardial Performance after Successful Liver Transplantation.International journal of organ transplantation medicine · 2016Article
- Extrahepatic complications to cirrhosis and portal hypertension: haemodynamic and homeostatic aspects.World journal of gastroenterology · 2014Review
- Cirrhotic cardiomyopathy: a cardiologist's perspective.World journal of gastroenterology · 2014Review
- Effect of biliary cirrhosis on neurogenic relaxation of rat gastric fundus and anococcygeus muscle: role of nitric oxide pathway.Digestive diseases and sciences · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular abnormalities accompany both portal hypertension and cirrhosis. These consist of hyperdynamic circulation, defined as reduced mean arterial pressure and systemic vascular resistance, and increased cardiac output. Despite the baseline increased cardiac output, ventricular inotropic and chronotropic responses to stimuli are blunted, a condition known as cirrhotic cardiomyopathy. Both conditions may play an initiating or aggravating pathogenic role in many of the complications of liver failure or portal hypertension including ascites, variceal bleeding, hepatorenal syndrome and increased postoperative mortality after major surgery or liver transplantation. This review briefly examines the major mechanisms that may underlie these cardiovascular abnormalities, concentrating on nitric oxide, endogenous cannabinoids, central neural activation and adrenergic receptor changes. Future work should address the complex interrelationships between these systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.