ArticleWorld journal of gastroenterology2006
Microproteinuria in patients with inflammatory bowel disease: is it associated with the disease activity or the treatment with 5-aminosalicylic acid?
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Inflammatory bowel disease increases the levels of albuminuria and the risk of urolithiasis: a two-sample Mendelian randomization study.European journal of medical research · 2023Pooled it
- Distinct clinicopathological features of IgA nephropathy associated with Crohn's disease: comparison with ulcerative colitis and non-IBD IgA nephropathy.Clinical and experimental nephrology · 2026Article
- Insights into renal and urological complications of inflammatory bowel disease.World journal of nephrology · 2024Review
- The pathological and outcome characteristics of renal lesions in Crohn's disease.BMC nephrology · 2022Review
- Renal Manifestations in Inflammatory Bowel Disease: A Cohort Study During the Biologic Era.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
- Prevalence of Renal Stones Among Patients With Inflammatory Bowel Disease in Saudi Arabia.Cureus · 2021Article
- Tubulointerstitial nephritis: diagnosis, treatment, and monitoring.Pediatric nephrology (Berlin, Germany) · 2017Review
- Extraintestinal manifestations and complications in IBD.Nature reviews. Gastroenterology & hepatology · 2013Review
- Inflammatory bowel disease: Looking beyond the tract.International journal of immunopathology and pharmacologyReview
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate whether microproteinuria in patients with inflammatory bowel disease (IBD) is associated with the disease activity or the treatment with 5-aminosalicylic acid (5-ASA).
methodsWe prospectively studied microproteinuria in 86 consecutive patients with IBD, 61 with ulcerative colitis (UC) and 25 with Crohn's disease (CD), before as well as 2 and 6 months after their inclusion in the study. Forty-six patients received 5-ASA for a period of 28.8 months (range 1-168 mo). Microalbuminuria (mALB) and urine levels of the renal tubular proteins beta2-microglobulin (beta2mGLB) and beta-N-acetyl-D-glucosamidase (beta-NAG) as well as the creatinine clearance were determined in a 12-h overnight urine collection. Tumor necrosis factor-alpha (TNF-alpha) serum levels were also measured.
resultsA total of 277 measurements (194 in UC patients and 83 in CD patients) were performed. The prevalence of abnormal microproteinuria in UC and CD patients was 12.9% and 6.0% for mALB, 22.7% and 27.7% for beta2mGLB, and 11.3% and 8.4% for beta-NAG, respectively. mALB was not associated with IBD activity. Beta2mGLB and beta-NAG urine levels were correlated to UC activity (UCAI: P<0.01; UCEI: P<0.005). mALB in UC patients and beta-NAG urine levels in CD patients were related to TNF-alpha serum levels. An association was noticed between microproteinuria and smoking habit. Treatment with 5-ASA was not correlated to the severity of microproteinuria or to the changes of creatinine clearance.
conclusionMicroproteinuria is mainly associated with UC and its activity but not affected by 5-ASA.
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