ArticleBritish journal of pharmacology2006
Suppression of pancreatitis-related allodynia/hyperalgesia by proteinase-activated receptor-2 in mice.
Article in British journal of pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 55 citations in OpenAlex.
- From Inflammation to Neuroplasticity: Molecular Mechanisms of Pain in Acute, Recurrent and Chronic Pancreatitis.International journal of molecular sciences · 2026Review
- Pharmacologic Modulation of the PAR-2-ERK Axis by Statins Converts Inflammatory Survival Signalling into Apoptosis in Colorectal Cancer Cells.International journal of molecular sciences · 2026Article
- Electrophysiological and Proteomic Evidence of Protease-Mediated Pro-nociceptive Signaling in Inflammatory Bowel Disease Patients.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Proteolytic activity ofThe journal of venomous animals and toxins including tropical diseases · 2021Article
- The cellular basis of protease-activated receptor 2-evoked mechanical and affective pain.JCI insight · 2020Article
- Nitric Oxide Stimulates Acute Pancreatitis Pain via Activating the NF-Oxidative medicine and cellular longevity · 2020Article
- Animal Models: Challenges and Opportunities to Determine Optimal Experimental Models of Pancreatitis and Pancreatic Cancer.Pancreas · 2019Review
- Macrophage-derived HMGB1 as a Pain Mediator in the Early Stage of Acute Pancreatitis in Mice: Targeting RAGE and CXCL12/CXCR4 Axis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2017Article
- Current understanding of the neuropathophysiology of pain in chronic pancreatitis.World journal of gastrointestinal pathophysiology · 2015Review
- Article
- Pathway-selective antagonism of proteinase activated receptor 2.British journal of pharmacology · 2014Article
- Development and evaluation of small peptidomimetic ligands to protease-activated receptor-2 (PAR2) through the use of lipid tethering.PloS one · 2014Article
- Development of highly potent protease-activated receptor 2 agonists via synthetic lipid tethering.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Trypsin reduces pancreatic ductal bicarbonate secretion by inhibiting CFTR Cl⁻ channels and luminal anion exchangers.Gastroenterology · 2011Article
- Serine proteases mediate inflammatory pain in acute pancreatitis.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Blockade of NGF and trk receptors inhibits increased peripheral mechanical sensitivity accompanying cystitis in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- Gastrointestinal roles for proteinase-activated receptors in health and disease.British journal of pharmacology · 2008Review
- Enkephalin-encoding herpes simplex virus-1 decreases inflammation and hotplate sensitivity in a chronic pancreatitis model.Molecular pain · 2008Article
- Cannabinoids ameliorate pain and reduce disease pathology in cerulein-induced acute pancreatitis.Gastroenterology · 2007Article
- Pain in chronic pancreatitis: a salutogenic mechanism or a maladaptive brain response?Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2007Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1 Proteinase-activated receptor-2 (PAR2), a receptor activated by trypsin and tryptase, is abundantly expressed in the gastrointestinal tract including the C-fiber terminal, and might play a role in processing of visceral pain. In the present study, we examined and characterized the roles of PAR2 in pancreatitis-related abdominal hyperalgesia/allodynia in mice. 2 Caerulein, administered i.p. once, caused a small increase in abdominal sensitivity to stimulation with von Frey hairs, without causing pancreatitis, in PAR2-knockout (KO) mice, but not wild-type (WT) mice. 3 Caerulein, given hourly six times in total, caused more profound abdominal hyperalgesia/allodynia in PAR2-KO mice, as compared with WT mice, although no significant differences were detected in the severity of pancreatitis between the KO and WT animals. 4 The PAR2-activating peptide, 2-furoyl-LIGRL-NH(2), coadministered repeatedly with caerulein six times in total, abolished the caerulein-evoked abdominal hyperalgesia/allodynia in WT, but not PAR2-KO, mice. Repeated doses of 2-furoyl-LIGRL-NH(2) moderately attenuated the severity of caerulein-induced pancreatitis in WT animals. 5 Our data from experiments using PAR2-KO mice provide evidence that PAR2 functions to attenuate pancreatitis-related abdominal hyperalgesia/allodynia without affecting pancreatitis itself, although the PAR2AP applied exogenously is not only antinociceptive but also anti-inflammatory.
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