ArticleGenome research2006
X chromosomes and autosomes evolve at similar rates in Drosophila: no evidence for faster-X protein evolution.
Article in Genome research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 72 citations in OpenAlex.
- Faster adaptation but slower divergence of X chromosomes under paternal genome elimination.Nature communications · 2025Article
- Chromosome-Aware Phylogenomics of Assassin Bugs (Hemiptera: Reduvioidea) Elucidates Ancient Gene Conflict.Molecular biology and evolution · 2023Article
- A Study of Faster-Z Evolution in the Great Tit (Parus major).Genome biology and evolution · 2020Article
- Genomic analysis of the four ecologically distinct cactus host populations of Drosophila mojavensis.BMC genomics · 2019Article
- Evidence for Faster X Chromosome Evolution in Spiders.Molecular biology and evolution · 2019Article
- Sexually dimorphic gene expression and transcriptome evolution provide mixed evidence for a fast-Z effect in Heliconius.Journal of evolutionary biology · 2019Article
- Molecular Population Genetics.Genetics · 2017Review
- Molecular Mechanisms and Evolutionary Processes Contributing to Accelerated Divergence of Gene Expression on the Drosophila X Chromosome.Molecular biology and evolution · 2015Article
- A Genome-wide hybrid incompatibility landscape between Caenorhabditis briggsae and C. nigoni.PLoS genetics · 2015Article
- Sex-specific trans-regulatory variation on the Drosophila melanogaster X chromosome.PLoS genetics · 2015Article
- Article
- Hybrid incompatibilities are affected by dominance and dosage in the haplodiploid wasp Nasonia.Frontiers in genetics · 2015Article
- Faster-X effects in two Drosophila lineages.Genome biology and evolution · 2014Article
- Positive selection drives faster-Z evolution in silkmoths.Evolution; international journal of organic evolution · 2014Article
- Article
- Faster-X adaptive protein evolution in house mice.Genetics · 2014Article
- The faster-X effect: integrating theory and data.Trends in genetics : TIG · 2013Review
- Comparative sex chromosome genomics in snakes: differentiation, evolutionary strata, and lack of global dosage compensation.PLoS biology · 2013Article
- Article
- Rate of amino acid substitution is influenced by the degree and conservation of male-biased transcription over 50 myr of Drosophila evolution.Genome biology and evolution · 2012Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent data from Drosophila suggest that a substantial fraction of amino acid substitutions observed between species are beneficial. If these beneficial mutations are on average partially recessive, then the rate of protein evolution is predicted to be faster for X-linked genes compared to autosomal genes (the "faster-X" hypothesis). We test this prediction by comparing rates of protein substitutions between orthologous genes, taking advantage of variations in chromosome fusions within the genus Drosophila. In members of the Drosophila melanogaster species group, the chromosomal arm 3L segregates as an ordinary autosome (i.e., two homologous copies in both males and females). However, in the Drosophila pseudoobscura species group, this chromosomal arm has become fused to the ancestral X chromosome and is hemizygous in males. The faster-X hypothesis predicts that protein evolution should be faster for genes on this chromosomal arm in the D. pseudoobscura lineage, relative to the D. melanogaster lineage. Here we combine new sequence data for 202 gene fragments in Drosophila miranda (in the pseudoobscura species group) with the completed genomes of D. melanogaster, D. pseudoobscura, and Drosophila yakuba to show that there are no detectable differences in rates of amino acid evolution for orthologous X-linked and autosomal genes. Our results imply that the contribution of the faster-X (if any) to the large-X effect on reproductive isolation in Drosophila is not due to a generally faster rate of protein evolution. The lack of a detectable faster-X effect in these species suggests either that beneficial amino acids are not partially recessive on average, or that adaptive evolution does not often use newly arising amino acid mutations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.