ArticleGenome research2006
Evolution of exon-intron structure and alternative splicing in fruit flies and malarial mosquito genomes.
Article in Genome research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 51 citations in OpenAlex.
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- Alternative Splicing Regulation of Cancer-Related Pathways in Caenorhabditis elegans: An In Vivo Model System with a Powerful Reverse Genetics Toolbox.International journal of cell biology · 2013Review
- SPLOOCE: a new portal for the analysis of human splicing variants.RNA biology · 2012Article
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- Origin and evolution of spliceosomal introns.Biology direct · 2012Review
- Transcriptome analysis of the silkworm (Bombyx mori) by high-throughput RNA sequencing.PloS one · 2012Article
- Changes in exon-intron structure during vertebrate evolution affect the splicing pattern of exons.Genome research · 2012Article
- Alternative splicing: a potential source of functional innovation in the eukaryotic genome.International journal of evolutionary biology · 2012Article
- Assessment of orthologous splicing isoforms in human and mouse orthologous genes.BMC genomics · 2010Article
- Genome-wide evidence for selection acting on single amino acid repeats.Genome research · 2010Article
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- Quantitative measures for the management and comparison of annotated genomes.BMC bioinformatics · 2009Article
- Sex-specific splicing in Drosophila: widespread occurrence, tissue specificity and evolutionary conservation.Genetics · 2009Article
- The effect of intron length on exon creation ratios during the evolution of mammalian genomes.RNA (New York, N.Y.) · 2008Article
- Alternative splicing and the steady-state ratios of mRNA isoforms generated by it are under strong stabilizing selection in Caenorhabditis elegans.Molecular biology and evolution · 2008Article
- A general definition and nomenclature for alternative splicing events.PLoS computational biology · 2008Article
- Alternative splicing: a missing piece in the puzzle of intron gain.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Comparative analysis of alternative splicing of orthologous genes from fruit flies (Drosophila melanogaster and Drosophila pseudoobscura) and mosquito (Anopheles gambiae) demonstrated that both in the fruit fly genes and in fruit fly-mosquito comparisons, constitutive exons and splicing sites are more conserved than alternative ones. While >97% of constitutive D. melanogaster exons are conserved in D. pseudoobscura, only approximately 80% of alternative exons are conserved. Similarly, 77% of constitutive fruit fly exons are conserved in the mosquito genes, compared with <50% of alternative exons. Internal alternatives are more conserved than terminal ones. Retained introns are the least conserved, alternative acceptor sites are slightly more conserved than donor sites, and mutually exclusive exons are almost as conserved as constitutive exons. Cassette and mutually exclusive exons experience almost no intron insertions. We also observed cases of interconversion of various elementary alternatives, e.g., transformation of cassette exons into alternative sites. These results agree with the observations made earlier in human-mouse comparisons and demonstrate that the phenomenon of relatively low conservation of alternatively spliced regions may be universal, as it has been observed in different taxonomic groups (mammals and insects) and at various evolutionary distances.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.