ArticleMammalian genome : official journal of the International Mammalian Genome Society2006
Estimating the number of coding mutations in genotypic- and phenotypic-driven N-ethyl-N-nitrosourea (ENU) screens.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Foxp2 loss of function increases striatal direct pathway inhibition via increased GABA release.Brain structure & function · 2018Article
- Mutations in Vps15 perturb neuronal migration in mice and are associated with neurodevelopmental disease in humans.Nature neuroscience · 2018Article
- Manipulation of dipeptidylpeptidase 10 in mouse and humanDisease models & mechanisms · 2018Article
- Towards trans-diagnostic mechanisms in psychiatry: neurobehavioral profile of rats with a loss-of-function point mutation in the dopamine transporter gene.Disease models & mechanisms · 2017Article
- Mouse Models of NMNAT1-Leber Congenital Amaurosis (LCA9) Recapitulate Key Features of the Human Disease.The American journal of pathology · 2016Article
- Germline mutation rates and the long-term phenotypic effects of mutation accumulation in wild-type laboratory mice and mutator mice.Genome research · 2015Article
- Nmf9 Encodes a Highly Conserved Protein Important to Neurological Function in Mice and Flies.PLoS genetics · 2015Article
- Article
- Functional analysis of a novel ENU-induced PHD finger 11 (Phf11) mouse mutant.Mammalian genome : official journal of the International Mammalian Genome Society · 2014Article
- 8-oxoguanine causes spontaneous de novo germline mutations in mice.Scientific reports · 2014Article
- Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition.Nature communications · 2013Article
- No evidence for cardiac dysfunction in Kif6 mutant mice.PloS one · 2013Article
- High throughput sequencing approaches to mutation discovery in the mouse.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Review
- Dual function of the UNC-45b chaperone with myosin and GATA4 in cardiac development.Journal of cell science · 2012Article
- Article
- A mouse model of early-onset renal failure due to a xanthine dehydrogenase nonsense mutation.PloS one · 2012Article
- Systematic generation of in vivo G protein-coupled receptor mutants in the rat.The pharmacogenomics journal · 2011Article
- Male hypogonadism and germ cell loss caused by a mutation in Polo-like kinase 4.Endocrinology · 2011Article
- Conserved role of unc-79 in ethanol responses in lightweight mutant mice.PLoS genetics · 2010Article
- Discovery of candidate disease genes in ENU-induced mouse mutants by large-scale sequencing, including a splice-site mutation in nucleoredoxin.PLoS genetics · 2009Article
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3 authors.
Funding
Abstract
N-ethyl-N-nitrosourea (ENU) is a widely used mutagen in genotypic and phenotypic screens aimed at elucidating gene function. The high rate at which ENU induces point mutations raises the possibility that an observed phenotype may be to the result of another unidentified linked mutation. This article presents methods for estimating the probability of additional linked coding mutations (1) in a given region of DNA using both Poisson and Bayesian models and in (2) an F(1) animal exposed to ENU that has undergone b number of backcrosses. Applying these methods to the mouse data set of Quwailid et al., we estimate that the probability that a confounding mutation is linked to a cloned mutation when the candidate region is 5 Mb is very slim (p < 0.002). Where mutants are identified by genotypic methods, we show that backcrossing in the absence of marker-assisted selection is an inefficient means of eliminating linked confounding mutations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.