ArticleImmunogenetics2006
Polymorphism of two very similar MHC class Ib loci in rainbow trout (Oncorhynchus mykiss).
Article in Immunogenetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Review
- Intra-specific copy number variation of MHC class II genes in the Siamese fighting fish.Immunogenetics · 2022Article
- MHC class I evolution; from Northern pike to salmonids.BMC ecology and evolution · 2021Article
- Article
- Distribution of ancient α1 and α2 domain lineages between two classical MHC class I genes and their alleles in grass carp.Immunogenetics · 2019Article
- Review
- Microbial Danger Signals Control Transcriptional Induction of Distinct MHC Class I L Lineage Genes in Atlantic Salmon.Frontiers in immunology · 2019Article
- Major histocompatibility complex (MHC) fragment numbers alone - in Atlantic cod and in general - do not represent functional variability.F1000Research · 2018Article
- Evolution of innate-like T cells and their selection by MHC class I-like molecules.Immunogenetics · 2016Review
- MHC and Evolution in Teleosts.Biology · 2016Review
- A comprehensive analysis of teleost MHC class I sequences.BMC evolutionary biology · 2015Article
- Unraveling the evolution of the Atlantic cod's (Gadus morhua L.) alternative immune strategy.PloS one · 2013Article
- Signatures of natural selection among lineages and habitats in Oncorhynchus mykiss.Ecology and evolution · 2012Article
- Comprehensive analysis of MHC class I genes from the U-, S-, and Z-lineages in Atlantic salmon.BMC genomics · 2010Article
- Genomic organization of duplicated major histocompatibility complex class I regions in Atlantic salmon (Salmo salar).BMC genomics · 2007Article
- Suggestive association of major histocompatibility IB genetic markers with resistance to bacterial cold water disease in rainbow trout (Oncorhynchus mykiss).Marine biotechnology (New York, N.Y.)Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As part of an ongoing elucidation of rainbow trout major histocompatibility complex (MHC) class I, the polymorphism of two MHC class Ib loci was analyzed. These loci, Onmy-UCA and Onmy-UDA, are situated head-to-tail and share more than 89% nucleotide identity in their open reading frames. They share 80% identity with some trout Ia alleles. The deduced amino acid sequences suggest that the UCA and UDA molecules are transported to endosomal compartments and may bind peptides in their binding groove. Our survey revealed seven UCA and eight UDA alleles. Similarity indices overlap when comparing within and between UCA and UDA alleles and some cross-locus motif variation is observed. In most trout both UCA and UDA transcripts were found. However, there probably is functional redundancy, because some trout lacked transcription of one of the two loci. Furthermore, for some UCA and UDA alleles, splicing deficiencies, early stop codons, and upstream start codons were found, which may interfere with efficient protein expression. The present study is the first extensive report on MHC class Ib polymorphism assigned to locus in ectotherm species.
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