ArticlePLoS genetics2006
DNA sequences shaped by selection for stability.
Article in PLoS genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Theory for sequence selection via phase separation and oligomerization.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- High Transcriptional Error Rates Vary as a Function of Gene Expression Level.Genome biology and evolution · 2020Article
- Article
- Refining the Ambush Hypothesis: Evidence That GC- and AT-Rich Bacteria Employ Different Frameshift Defence Strategies.Genome biology and evolution · 2018Article
- Both Maintenance and Avoidance of RNA-Binding Protein Interactions Constrain Coding Sequence Evolution.Molecular biology and evolution · 2017Article
- Common position of indels that cause deviations from canonical genome organization in different measles virus strains.Virology journal · 2016Article
- Purifying Selection on Exonic Splice Enhancers in Intronless Genes.Molecular biology and evolution · 2016Article
- Mathematical and live meningococcal models for simple sequence repeat dynamics - coherent predictions and observations.PloS one · 2014Article
- Article
- Evolution of coding microsatellites in primate genomes.Genome biology and evolution · 2013Article
- Evolutionary pressures on simple sequence repeats in prokaryotic coding regions.Nucleic acids research · 2012Article
- Error prevention and mitigation as forces in the evolution of genes and genomes.Nature reviews. Genetics · 2011Review
- Quantification of codon selection for comparative bacterial genomics.BMC genomics · 2011Article
- The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes.PloS one · 2011Article
- Overlapping codes within protein-coding sequences.Genome research · 2010Article
- Unstable DNA repair genes shaped by their own sequence modifying phenotypes.Journal of molecular evolution · 2010Article
- The expansion of amino-acid repeats is not associated to adaptive evolution in mammalian genes.BMC genomics · 2009Article
- Expansion of tandem repeats in sea anemone Nematostella vectensis proteome: A source for gene novelty?BMC genomics · 2009Article
- Mononucleotide repeats are asymmetrically distributed in fungal genes.BMC genomics · 2008Article
- Stabilization of the genome of the mismatch repair deficient Mycobacterium tuberculosis by context-dependent codon choice.BMC genomics · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sequence of a stretch of nucleotides affects its propensity for errors during replication and expression. Are proteins encoded by stable or unstable nucleotide sequences? If selection for variability is prevalent, one could expect an excess of unstable sequences. Alternatively, if selection against targets for errors were substantial, an excess of stable sequences would be expected. We screened the genome sequences of different organisms for an important determinant of stability, the presence of mononucleotide repeats. We find that codons are used to encode proteins in a way that avoids the emergence of mononucleotide repeats, and we can attribute this bias to selection rather than a neutral process. This indicates that selection for stability, rather than for the generation of variation, substantially influences how information is encoded in the genome.
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