ArticlePLoS genetics2006
Analysis of ribosomal protein gene structures: implications for intron evolution.
Article in PLoS genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The spread of the first introns in proto-eukaryotic paralogs.Communications biology · 2022Article
- Regulation of ribosomal protein genes: An ordered anarchy.Wiley interdisciplinary reviews. RNA · 2021Review
- Current Bacterial Gene Encoding Capsule Biosynthesis Protein CapI Contains Nucleotides Derived from Exonization.Evolutionary bioinformatics online · 2016Article
- Novel Introner-Like Elements in fungi Are Involved in Parallel Gains of Spliceosomal Introns.PloS one · 2015Article
- Origin of spliceosomal introns and alternative splicing.Cold Spring Harbor perspectives in biology · 2014Article
- Community structure detection for overlapping modules through mathematical programming in protein interaction networks.PloS one · 2014Article
- Comparative genomics of eukaryotic small nucleolar RNAs reveals deep evolutionary ancestry amidst ongoing intragenomic mobility.BMC evolutionary biology · 2012Article
- Structural and functional characterization of ribosomal protein gene introns in sponges.PloS one · 2012Article
- Evolution of GHF5 endoglucanase gene structure in plant-parasitic nematodes: no evidence for an early domain shuffling event.BMC evolutionary biology · 2008Article
- Spliceosomal introns as tools for genomic and evolutionary analysis.Nucleic acids research · 2008Review
- Intron mis-splicing: no alternative?Genome biology · 2008Review
- Functional and evolutionary analysis of alternatively spliced genes is consistent with an early eukaryotic origin of alternative splicing.BMC evolutionary biology · 2007Article
- Ancient intron insertion sites and palindromic genomic duplication evolutionally shapes an elementally functioning membrane protein family.BMC evolutionary biology · 2007Article
- Screening and cloning for proteins transactivated by the PS1TP5 protein of hepatitis B virus: a suppression subtractive hybridization study.World journal of gastroenterology · 2007Article
- Intron dynamics in ribosomal protein genes.PloS one · 2007Article
- Characterization of intron loss events in mammals.Genome research · 2007Article
- An overabundance of phase 0 introns immediately after the start codon in eukaryotic genes.BMC genomics · 2006Article
- Phase distribution of spliceosomal introns: implications for intron origin.BMC evolutionary biology · 2006Article
- The origin of introns and their role in eukaryogenesis: a compromise solution to the introns-early versus introns-late debate?Biology direct · 2006Article
- A high density of ancient spliceosomal introns in oxymonad excavates.BMC evolutionary biology · 2006Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many spliceosomal introns exist in the eukaryotic nuclear genome. Despite much research, the evolution of spliceosomal introns remains poorly understood. In this paper, we tried to gain insights into intron evolution from a novel perspective by comparing the gene structures of cytoplasmic ribosomal proteins (CRPs) and mitochondrial ribosomal proteins (MRPs), which are held to be of archaeal and bacterial origin, respectively. We analyzed 25 homologous pairs of CRP and MRP genes that together had a total of 527 intron positions. We found that all 12 of the intron positions shared by CRP and MRP genes resulted from parallel intron gains and none could be considered to be "conserved," i.e., descendants of the same ancestor. This was supported further by the high frequency of proto-splice sites at these shared positions; proto-splice sites are proposed to be sites for intron insertion. Although we could not definitively disprove that spliceosomal introns were already present in the last universal common ancestor, our results lend more support to the idea that introns were gained late. At least, our results show that MRP genes were intronless at the time of endosymbiosis. The parallel intron gains between CRP and MRP genes accounted for 2.3% of total intron positions, which should provide a reliable estimate for future inferences of intron evolution.
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