ArticlePLoS computational biology2006
Large-scale trends in the evolution of gene structures within 11 animal genomes.
Article in PLoS computational biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 85 citations in OpenAlex.
- Phylogenetic Analysis of 590 Species Reveals Distinct Evolutionary Patterns of Intron-Exon Gene Structures Across Eukaryotic Lineages.Molecular biology and evolution · 2024Article
- Genome-wide identification of R2R3-MYB family genes and gene response to stress in ginger.The plant genome · 2024Article
- Protein length distribution is remarkably uniform across the tree of life.Genome biology · 2023Article
- Regulated splicing of large exons is linked to phase-separation of vertebrate transcription factors.The EMBO journal · 2021Article
- A Genome-Wide Identification of the WRKY Family Genes and a Survey of Potential WRKY Target Genes in Dendrobium officinale.Scientific reports · 2017Article
- COGNATE: comparative gene annotation characterizer.BMC genomics · 2017Article
- Gene length as a biological timer to establish temporal transcriptional regulation.Cell cycle (Georgetown, Tex.) · 2017Article
- The Agassiz's desert tortoise genome provides a resource for the conservation of a threatened species.PloS one · 2017Article
- Splice Sites Seldom Slide: Intron Evolution in Oomycetes.Genome biology and evolution · 2016Article
- Uridylation of RNA Hairpins by Tailor Confines the Emergence of MicroRNAs in Drosophila.Molecular cell · 2015Article
- A novel model for development, organization, and function of gonadotropes in fish pituitary.Frontiers in endocrinology · 2014Article
- Reverse transcriptase and intron number evolution.Stem cell investigation · 2014Article
- Accumulation of CTCF-binding sites drives expression divergence between tandemly duplicated genes in humans.BMC genomics · 2014Article
- Analysis of phylogenetic signal in protostomial intron patterns using Mutual Information.Theory in biosciences = Theorie in den Biowissenschaften · 2013Article
- Article
- Widespread polymorphism in the positions of stop codons in Drosophila melanogaster.Genome biology and evolution · 2012Article
- ASGARD: an open-access database of annotated transcriptomes for emerging model arthropod species.Database : the journal of biological databases and curation · 2012Article
- In with the old, in with the new: the promiscuity of the duplication process engenders diverse pathways for novel gene creation.International journal of evolutionary biology · 2012Article
- Comparative genomics approach to detecting split-coding regions in a low-coverage genome: lessons from the chimaera Callorhinchus milii (Holocephali, Chondrichthyes).Briefings in bioinformatics · 2011Article
- Global analysis of disease-related DNA sequence variation in 10 healthy individuals: implications for whole genome-based clinical diagnostics.Genetics in medicine : official journal of the American College of Medical Genetics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
We have used the annotations of six animal genomes (Homo sapiens, Mus musculus, Ciona intestinalis, Drosophila melanogaster, Anopheles gambiae, and Caenorhabditis elegans) together with the sequences of five unannotated Drosophila genomes to survey changes in protein sequence and gene structure over a variety of timescales--from the less than 5 million years since the divergence of D. simulans and D. melanogaster to the more than 500 million years that have elapsed since the Cambrian explosion. To do so, we have developed a new open-source software library called CGL (for "Comparative Genomics Library"). Our results demonstrate that change in intron-exon structure is gradual, clock-like, and largely independent of coding-sequence evolution. This means that genome annotations can be used in new ways to inform, corroborate, and test conclusions drawn from comparative genomics analyses that are based upon protein and nucleotide sequence similarities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.