Evidence map›Paper›PMID 16517886›Full record

ArticleJournal of clinical microbiology2006

Validation of string test for diagnosis of Helicobacter pylori infections.

Billie Velapatiño, Jacqueline Balqui, Robert H Gilman, Alejandro Bussalleu, Willi Quino, S Alison Finger, Livia Santivañez, Phabiola Herrera, Alejandro Piscoya, Jose Valdivia and 2 more

Open access · greenAbstract readComparative StudyValidation Study
In one paragraph

Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

  1. CurrentJGH open : an open access journal of gastroenterology and hepatology · 2026
    Review
  2. Prevalence ofMedicina (Kaunas, Lithuania) · 2020
    Review
  3. Helicobacter pylori infection in children: an overview of diagnostic methods.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Review
  4. Helicobacter pylori Infection in Rural and Urban Dyspeptic Patients from Venezuela.The American journal of tropical medicine and hygiene · 2015
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Billie VelapatiñoAsociación Benéfica PRISMA, Lima, Perú.
Jacqueline Balqui
Robert H Gilman
Alejandro Bussalleu
Willi Quino
S Alison Finger
Livia Santivañez
Phabiola Herrera
Alejandro Piscoya
Jose Valdivia
Jaime Cok
Douglas E Berg
Universidad Peruana Cayetano Heredia · PEPrisma · PEWashington University in St. Louis · US

Funding

Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
H.PYLORI POPULATION GENETICS AND GENOME EVOLUTIONR01DK063041 · NIDDK · WASHINGTON UNIVERSITY · PI BERG, DOUGLAS EUGENE · 2003 to 2007
$1.6M
DRUG RESISTANCE AND GENE TRANSFER IN H PYLORIR01AI038166 · NIAID · WASHINGTON UNIVERSITY · PI BERG, DOUGLAS EUGENE · 1995 to 2003
$1.1M
TUTORIAL IN TROPICAL HEALTH AT JHU/PERU OVERSEAS SITEST35AI007646 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GILMAN, ROBERT H · 2000 to 2004
$457k
NIAID NIH HHS P01 AI 52976-01NIAID NIH HHS R01 AI38166NIAID NIH HHS T35 AI007646NIAID NIH HHS T35 AI07646NIDDK NIH HHS P30 DK052574NIDDK NIH HHS P30 DK52574NIDDK NIH HHS R01 DK063041NIDDK NIH HHS R01 DK 63041
6 · The paper itself

Abstract

The method of recovering Helicobacter pylori DNA or viable cells absorbed on a string that a person has swallowed and that is retrieved an hour later (string test) should be a useful alternative to traditional analysis of cells or DNA obtained by endoscopy, which is invasive, uncomfortable, relatively costly, and ill-suited for community-based and pediatric studies. Here we assayed the sensitivity and validity of the string test versus conventional endoscopic biopsy for detecting and analyzing H. pylori infection. Forty-four people with gastric complaints were studied using both H. pylori culture and urease gene (ureB) PCR. H. pylori organisms cultured from strings and biopsy specimens from the same patients were fingerprinted by the randomly amplified polymorphic DNA (RAPD) method. Biopsy sections were also hematoxylin and eosin and silver stained for H. pylori detection. H. pylori was cultured from 80% of strings and detected by PCR from 91% of strings from participants whose biopsies had been H. pylori positive by culture, PCR, and/or histology. Strains recovered from strings and biopsy specimens yielded identical or closely related RAPD profiles in each of the 24 cases tested. We conclude that the string test is a useful method for H. pylori recovery and analysis when relatively noninvasive procedures are needed.

Indexed as

AdultBacteriological TechniquesBase SequenceDNA, BacterialEndoscopyFemaleGenes, BacterialHelicobacter InfectionsHelicobacter pyloriHumansMaleMiddle AgedSensitivity and SpecificityUreaseDNA, BacterialUrease

Identifiers

PMID16517886
PMCPMC1393125
OpenAlexW2129729831

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.