ArticleJournal of clinical microbiology2006
A successful, diverse disease-associated lineage of nontypeable pneumococci that has lost the capsular biosynthesis locus.
Article in Journal of clinical microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Storage stability of non-encapsulated pneumococci in saliva is dependent on null-capsule clade, with strains carryingMicrobiology (Reading, England) · 2025Article
- An abundance ofMicrobiology (Reading, England) · 2025Article
- Convergent impact of vaccination and antibiotic pressures on pneumococcal populations.Cell chemical biology · 2024Review
- Beneath the surface: a case report on nonencapsulatedAccess microbiology · 2024Article
- The Streptococcus pyogenes hyaluronic acid capsule promotes experimental nasal and skin infection by preventing neutrophil-mediated clearance.PLoS pathogens · 2022Article
- Identification and molecular epidemiology of routinely determined Streptococcus pneumoniae with negative Quellung reaction results.Journal of clinical laboratory analysis · 2022Article
- Absence ofMicroorganisms · 2022Article
- PCR and Culture Analysis ofMicroorganisms · 2021Article
- The Best of All Worlds:Microorganisms · 2019Review
- Genomic differences among carriage and invasive nontypeable pneumococci circulating in South Africa.Microbial genomics · 2019Article
- Peptide Occurring in Enterobacteriaceae TriggersFrontiers in cellular and infection microbiology · 2019Article
- Foreign peptide triggers boost in pneumococcal metabolism and growth.BMC microbiology · 2018Article
- Article
- Review
- Streptococcus pneumoniae capsule determines disease severity in experimental pneumococcal meningitis.Open biology · 2016Article
- Comparative Genome Analyses of Streptococcus suis Isolates from Endocarditis Demonstrate Persistence of Dual Phenotypic Clones.PloS one · 2016Article
- Nonencapsulated Streptococcus pneumoniae causes otitis media during single-species infection and during polymicrobial infection with nontypeable Haemophilus influenzae.Pathogens and disease · 2015Article
- Mechanisms of genome evolution of Streptococcus.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2015Review
- Global phylogenomic analysis of nonencapsulated Streptococcus pneumoniae reveals a deep-branching classic lineage that is distinct from multiple sporadic lineages.Genome biology and evolution · 2014Article
- Diversification of bacterial genome content through distinct mechanisms over different timescales.Nature communications · 2014Article
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5 authors.
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Abstract
Streptococcus pneumoniae strains which fail to produce a polysaccharide capsule are commonly isolated from carriage and disease contexts. Here we use a multilocus approach to distinguish genuine nontypeable pneumococci from closely related nontypeable streptococcal isolates in a data set of 121 untypeable pneumococci from nasopharyngeal swabs and middle ear fluid of Finnish children and demonstrate that 70 of these belong to a pneumococcal lineage which has lost its capsular locus. Strains of this relatively old lineage include sequence types 344, 448, and 449. Comparison with the multilocus sequence typing database shows that strains of this lineage have spread intercontinentally and have been isolated from carriage, mucosal, and invasive disease. Furthermore we note a particular association of this nontypeable lineage with outbreaks of conjunctivitis. The diversification and geographic spread of this lineage suggest that loss of capsule is not inconsistent with long-term persistence and raise questions about the capsule's role in pneumococcal transmission.
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