ArticleThe Plant cell2006
FaQR, required for the biosynthesis of the strawberry flavor compound 4-hydroxy-2,5-dimethyl-3(2H)-furanone, encodes an enone oxidoreductase.
Article in The Plant cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 178 citations in OpenAlex.
- Genome-wide discovery and characterization of terpene synthases contributing to strawberry aroma metabolism.Plant physiology · 2026Article
- Functional Characterization of Enone Oxidoreductase Orthologs Highlights Hidden Furaneol Biosynthetic Capacity in Apples.Journal of agricultural and food chemistry · 2026Article
- Promiscuous Transferases Malonylate Furaneol Glucoside inJournal of agricultural and food chemistry · 2026Article
- Untargeted metabolomics based on HS- SPME-GC-MS revealing the dynamic evolution of aroma components during cigar aging.Frontiers in plant science · 2025Article
- AUXIN RESPONSE FACTOR 2 mediates repression of strawberry receptacle ripening via auxin-ABA interplay.Plant physiology · 2024Article
- Urinary Biomarkers of Strawberry and Blueberry Intake.Metabolites · 2024Article
- Construction of aFood science & nutrition · 2024Article
- Metabolomics to understand metabolic regulation underpinning fruit ripening, development, and quality.Journal of experimental botany · 2024Review
- Advances in genomics and genome editing for improving strawberry (Frontiers in genetics · 2024Review
- Improvement of crop production in controlled environment agriculture through breeding.Frontiers in plant science · 2024Review
- DNA methylation mediated by RdDM pathway and demethylation affects furanone accumulation through regulation ofHorticulture research · 2023Article
- Abscisic acid mediated strawberry receptacle ripening involves the interplay of multiple phytohormone signaling networks.Frontiers in plant science · 2023Article
- An Integrated Metabolomic and Gene Expression Analysis of 'Sachinoka' Strawberry and Its Somaclonal Mutant Reveals Fruit Color and Volatiles Differences.Plants (Basel, Switzerland) · 2022Article
- A multi-omics framework reveals strawberry flavor genes and their regulatory elements.The New phytologist · 2022Article
- Importance of FaWRKY71 in Strawberry (International journal of molecular sciences · 2022Article
- Analysis and Comparison of Aroma Compounds of Brown Sugar in Guangdong, Guangxi and Yunnan Using GC-O-MS.Molecules (Basel, Switzerland) · 2022Article
- Azacytidine arrests ripening in cultivated strawberry (Fragaria × ananassa) by repressing key genes and altering hormone contents.BMC plant biology · 2022Article
- The R2R3-MYB transcription factor FaMYB63 participates in regulation of eugenol production in strawberry.Plant physiology · 2022Article
- Transcriptome analysis of the pulp of citrus fruitlets suggests that domestication enhanced growth processes and reduced chemical defenses increasing palatability.Frontiers in plant science · 2022Article
- Inheritance of esters and other volatile compounds responsible for the fruity aroma in strawberry.Frontiers in plant science · 2022Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The flavor of strawberry (Fragaria x ananassa) fruit is dominated by an uncommon group of aroma compounds with a 2,5-dimethyl-3(H)-furanone structure. We report the characterization of an enzyme involved in the biosynthesis of 4-hydroxy-2,5-dimethyl-3(2H)-furanone (HDMF; Furaneol), the key flavor compound in strawberries. Protein extracts were partially purified, and the observed distribution of enzymatic activity correlated with the presence of a single polypeptide of approximately 37 kD. Sequence analysis of two peptide fragments showed total identity with the protein sequence of a strongly ripening-induced, auxin-dependent putative quinone oxidoreductase, Fragaria x ananassa quinone oxidoreductase (FaQR). The open reading frame of the FaQR cDNA consists of 969 bp encoding a 322-amino acid protein with a calculated molecular mass of 34.3 kD. Laser capture microdissection followed by RNA extraction and amplification demonstrated the presence of FaQR mRNA in parenchyma tissue of the strawberry fruit. The FaQR protein was functionally expressed in Escherichia coli, and the monomer catalyzed the formation of HDMF. After chemical synthesis and liquid chromatography-tandem mass spectrometry analysis, 4-hydroxy-5-methyl-2-methylene-3(2H)-furanone was confirmed as a substrate of FaQR and the natural precursor of HDMF. This study demonstrates the function of the FaQR enzyme in the biosynthesis of HDMF as enone oxidoreductase and provides a foundation for the improvement of strawberry flavor and the biotechnological production of HDMF.
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