ArticleApplied and environmental microbiology2006
Heterologous expression of BetL, a betaine uptake system, enhances the stress tolerance of Lactobacillus salivarius UCC118.
Article in Applied and environmental microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed, 124 citations in OpenAlex.
- Enhancing Probiotic Performance in Food Matrices: From Strain Selection to Bioengineering.Journal of food science · 2026Review
- Exogenous KFrontiers in microbiology · 2026Article
- Recent Advances in the Understanding of Stress Resistance Mechanisms in Probiotics: Relevance for the Design of Functional Food Systems.Probiotics and antimicrobial proteins · 2025Review
- Development of chemically defined media for3 Biotech · 2023Article
- Recent advances in probiotication of fruit and vegetable juices.Journal of advanced veterinary and animal research · 2023Article
- Role of probiotics in prevention and treatment of enteric infections: a comprehensive review.3 Biotech · 2021Review
- Surface display of p75, a Lactobacillus rhamnosus GG derived protein, on Bacillus subtilis spores and its antibacterial activity against Listeria monocytogenes.AMB Express · 2020Article
- Natural and engineered promoters for gene expression in Lactobacillus species.Applied microbiology and biotechnology · 2020Review
- Intracellular osmoprotectant concentrations determine Propionibacterium freudenreichii survival during drying.Applied microbiology and biotechnology · 2020Article
- Transcriptomic and proteomic profiling revealed global changes in Streptococcus thermophilus during pH-controlled batch fermentations.Journal of microbiology (Seoul, Korea) · 2019Article
- Review: Adaptation of Beneficial Propionibacteria, Lactobacilli, and Bifidobacteria Improves Tolerance Toward Technological and Digestive Stresses.Frontiers in microbiology · 2019Review
- Metabolic Pathway Profiling in Intracellular and Extracellular Environments ofFrontiers in microbiology · 2019Article
- In a quest for engineering acidophiles for biomining applications: challenges and opportunities.Genes · 2018Review
- Probiotic engineering: towards development of robust probiotic strains with enhanced functional properties and for targeted control of enteric pathogens.Gut pathogens · 2017Review
- Advances in the Microbiome: Applications to Clostridium difficile Infection.Journal of clinical medicine · 2016Review
- Stress Physiology of Lactic Acid Bacteria.Microbiology and molecular biology reviews : MMBR · 2016Review
- Shedding light on betL*: pPL2-lux mediated real-time analysis of betL* expression in Listeria monocytogenes.Bioengineered · 2016Article
- Designer probiotics: Development and applications in gastrointestinal health.World journal of gastrointestinal pathophysiology · 2015Review
- Technology and potential applications of probiotic encapsulation in fermented milk products.Journal of food science and technology · 2015Review
- Impact on human health of microorganisms present in fermented dairy products: an overview.BioMed research international · 2015Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Given the increasing commercial and clinical relevance of probiotic cultures, improving the technological robustness of what are often process-sensitive cultures is an important biological goal. The nisin-controlled expression system was used to direct the heterologous expression of the listerial betaine uptake system BetL in the probiotic strain Lactobacillus salivarius UCC118. Following nisin induction, strains expressing betL exhibited a significant increase in resistance to several stresses, including elevated osmo-, cryo-, baro-, and chill tolerance, as well as increased resistance to spray- and freeze-drying. The ability to confer additional stress tolerance on a probiotic culture may be an important step in delivering viable cultures for maximal efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.