ArticleApplied and environmental microbiology2006
Chromosomal dynamism in progeny of outbreak-related sorbitol-fermenting enterohemorrhagic Escherichia coli O157:NM.
Article in Applied and environmental microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Article
- Rates of evolutionary change of resident Escherichia coli O157:H7 differ within the same ecological niche.BMC genomics · 2022Article
- Presence of Shiga Toxin-ProducingMicroorganisms · 2018Article
- Molecular Characterization of Human Atypical Sorbitol-Fermenting Enteropathogenic Escherichia coli O157 Reveals High Diversity.Journal of clinical microbiology · 2016Article
- Is Shiga Toxin-Negative Escherichia coli O157:H7 Enteropathogenic or Enterohemorrhagic Escherichia coli? Comprehensive Molecular Analysis Using Whole-Genome Sequencing.Journal of clinical microbiology · 2015Article
- Phylogeny of Shiga toxin-producing Escherichia coli O157 isolated from cattle and clinically ill humans.Molecular biology and evolution · 2012Article
- First report of the Shiga toxin 1 gene in sorbitol-fermenting Escherichia coli O157:H⁻.Journal of clinical microbiology · 2012Article
- Identification of intermediate in evolutionary model of enterohemorrhagic Escherichia coli O157.Emerging infectious diseases · 2012Article
- The highly virulent 2006 Norwegian EHEC O103:H25 outbreak strain is related to the 2011 German O104:H4 outbreak strain.PloS one · 2012Article
- Shiga toxin 2 overexpression in Escherichia coli O157:H7 strains associated with severe human disease.Microbial pathogenesis · 2011Article
- Escherichia coli O157:H7: animal reservoir and sources of human infection.Foodborne pathogens and disease · 2011Review
- Chromosomal instability in enterohaemorrhagic Escherichia coli O157:H7: impact on adherence, tellurite resistance and colony phenotype.Molecular microbiology · 2011Article
- Verotoxins in bovine and meat verotoxin-producing Escherichia coli isolates: type, number of variants, and relationship to cytotoxicity.Applied and environmental microbiology · 2011Article
- Impact of Pseudomonas aeruginosa genomic instability on the application of typing methods for chronic cystic fibrosis infections.Journal of clinical microbiology · 2010Article
- Sorbitol-fermenting Escherichia coli O157, Scotland.Emerging infectious diseases · 2010Article
- Analysis of the clonal relationship of serotype O26:H11 enterohemorrhagic Escherichia coli isolates from cattle.Applied and environmental microbiology · 2009Article
- Pathogenic potential of emergent sorbitol-fermenting Escherichia coli O157:NM.Infection and immunity · 2008Article
- Treatment and outcome of Shiga-toxin-associated hemolytic uremic syndrome (HUS).Pediatric nephrology (Berlin, Germany) · 2008Review
- The CI repressors of Shiga toxin-converting prophages are involved in coinfection of Escherichia coli strains, which causes a down regulation in the production of Shiga toxin 2.Journal of bacteriology · 2008Article
- Recycling of Shiga toxin 2 genes in sorbitol-fermenting enterohemorrhagic Escherichia coli O157:NM.Applied and environmental microbiology · 2008Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sorbitol-fermenting (SF) enterohemorrhagic Escherichia coli (EHEC) O157:NM (nonmotile) is a unique clone that causes outbreaks of hemorrhagic colitis and hemolytic-uremic syndrome. In well-defined clusters of cases, we have observed significant variability in pulsed-field gel electrophoresis (PFGE) patterns which could indicate coinfection by different strains. An analysis of randomly selected progeny colonies of an outbreak strain after subcultivation demonstrated that they displayed either the cognate PFGE outbreak pattern or one of four additional patterns and were <89% similar. These profound alterations were associated with changes in the genomic position of one of two Shiga toxin 2-encoding genes (stx2) in the outbreak strain or with the loss of this gene. The two stx2 alleles in the outbreak strain were identical but were flanked with phage-related sequences with only 77% sequence identity. Neither of these phages produced plaques, but one lysogenized E. coli K-12 and integrated in yecE in the lysogens and the wild-type strain. The presence of two stx2 genes which correlated with increased production of Stx2 in vitro but not with the clinical outcome of infection was also found in 14 (21%) of 67 SF EHEC O157:NM isolates from sporadic cases of human disease. The variability of PFGE patterns for the progeny of a single colony must be considered when interpreting PFGE patterns in SF EHEC O157-associated outbreaks.
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