ArticleApplied and environmental microbiology2006
Characterization of two polyketide synthase genes involved in zearalenone biosynthesis in Gibberella zeae.
Article in Applied and environmental microbiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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82 citing papers in PubMed, 206 citations in OpenAlex.
- Unravelling the Role of Non-Clustered Polyketide Synthases and Key Metabolites in Ochratoxin a Accumulation byInternational journal of molecular sciences · 2026Article
- Genome mining-based discovery of an atypical fungal non-reducing polyketide synthase encoding dimeric alkylresorcinol biosynthesis.The Journal of antibiotics · 2026Article
- Transformation of Alternaria dauci demonstrates the involvement of two polyketide synthase genes in aldaulactone production and fungal pathogenicity.Scientific reports · 2025Article
- The TOX2 Gene Is Responsible for Conidiation and Full Virulence inCurrent issues in molecular biology · 2025Article
- Diversity and Distribution of Non-Reducing Polyketide Synthases (NR-PKSs) in Ascomycota (Fungi).Journal of fungi (Basel, Switzerland) · 2025Article
- Review
- Multi-omics reveals the regulatory effects of Chinese herbal medicine substrates on secondary metabolite biosynthesis inFrontiers in microbiology · 2025Article
- Bacterial Lactonases ZenA with Noncanonical Structural Features Hydrolyze the Mycotoxin Zearalenone.ACS catalysis · 2024Article
- Occurrence ofInternational journal of microbiology · 2024Article
- Bioinformatic Analysis of Secondary Metabolite Biosynthetic Potential in PathogenicJournal of fungi (Basel, Switzerland) · 2023Article
- Inventory of the Secondary Metabolite Biosynthetic Potential of Members within the Terminal Clade of theJournal of fungi (Basel, Switzerland) · 2023Article
- Genome analysis of Cephalotrichum gorgonifer and identification of the biosynthetic pathway for rasfonin, an inhibitor of KRAS dependent cancer.Fungal biology and biotechnology · 2023Article
- Development and Evaluation of a Next-Generation Sequencing Panel for the Multiple Detection and Identification of Pathogens in Fermented Foods.Journal of microbiology and biotechnology · 2023Article
- Identification of polyketide synthase genes required for aspinolide biosynthesis in Trichoderma arundinaceum.Applied microbiology and biotechnology · 2022Article
- Zearalenone and Its Masked Forms in Cereals and Cereal-Derived Products: A Review of the Characteristics, Incidence, and Fate in Food Processing.Journal of fungi (Basel, Switzerland) · 2022Review
- Melatonin Protects the Histologic Structure of the Uterus in Conditions of Zearalenone Intake.Materia socio-medica · 2022Article
- Assembly, Annotation, and Comparative Whole Genome Sequence ofPathogens (Basel, Switzerland) · 2022Article
- Effect of Compactin on the Mycotoxin Production and Expression of Related Biosynthetic and Regulatory Genes in ToxigenicMicroorganisms · 2022Article
- Article
- Characterization of NRPS and PKS genes involved in the biosynthesis of SMs in Alternaria dauci including the phytotoxic polyketide aldaulactone.Scientific reports · 2022Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zearalenone, a mycotoxin produced by several Fusarium spp., is most commonly found as a contaminant in stored grain and has chronic estrogenic effects on mammals. Zearalenone is a polyketide derived from the sequential condensation of multiple acetate units by a polyketide synthase (PKS), but the genetics of its biosynthesis are not understood. We cloned two genes, designated ZEA1 and ZEA2, which encode polyketide synthases that participate in the biosynthesis of zearalenone by Gibberella zeae (anamorph Fusarium graminearum). Disruption of either gene resulted in the loss of zearalenone production under inducing conditions. ZEA1 and ZEA2 are transcribed divergently from a common promoter region. Quantitative PCR analysis of both PKS genes and six flanking genes supports the view that the two polyketide synthases make up the core biosynthetic unit for zearalenone biosynthesis. An appreciation of the genetics of zearalenone biosynthesis is needed to understand how zearalenone is synthesized under field conditions that result in the contamination of grain.
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